Collagen synthesis is increased in the aortas, mesenteric arteries, and to a lesser extent, in the hearts of rats either made hypertensive with desoxycorticosterone acetate-salt or that are spontaneously hypertensive. Several markers of collagen biosynthesis were shown to be increased, including prolyl hydroxylase (EC 1.14.11.2; proline, 2-oxoglutarate dioxygenase), prolyl hydroxylase-related a...

The induction of tyrosine hydroxylase in the nerve terminals of the rat heart by reserpine lags behind that in the stellate ganglion by two to three days. Cycloheximide given three days after reserpine blocks the further rise of the enzyme in the nerve terminals. The increase in tyrosine hydroxylase activity of the lumbar ganglion is as marked as that in the stellate ganglion. The increase of e...

Typical migraine headaches have been consistently induced by the administration of reserpine to migrainous patients. In such patients an increase in urinary excretion of histidine and lysine has been reported to accompany attacks of migraine (Kimball and Friedman, 1961; Menkes, 1964). These aminoacids have also been found in the oedema fluid which accumulates near the temporal arteries of patie...

The acetylcholine (ACh) levels in rat and mouse frontal cortex increased 155% and 124%, respectively, 24 h after ip reserpine 3 mg.kg-1. Striatal ACh contents, however, were diminished by 47% in rats and 80% in mice. ACh contents elevated 50% and scopolamine (Scop) depleted the ACh by 47% in mouse striatum 12 h following reserpine. Receptor binding assay showed that 24 h after reserpine the Bma...

T HE introduction of Rauwolfia serpentina into this country by Wilkins and Judsonl and the purification of an active alkaloid, reserpine (Serpasil), has led to the widespread clinical IIS~ of the iatter drug not only in hypertension2,3 but also in neuropsychiatric conditions.” The purpose of this report is to describe the development of psychiatric complications in hypertensive patients treated...

The effects of large doses of reserpine have been compared in hypertensive and norrmotensive patients. The falls of blood pressure are larger in the hvpertensives than in the normotensives. In normotensive animals small falls of blood pressure occur. Evidence is presented which suggests that the fall of blood pressure in animals is in part mediated through the sympathetic nervous system. There ...

Previous observations on rats have shown that reserpine free extract of R. Serpentina prevents the stress induced activation of adrenal cortex. The therapeutic success of R. Serpentina in clinical hypertension has stimulated extensive research recently. It has been observed that the drug has, in addition to the well marked hypotensive action, a tranquillising influence on the patient. Results o...

Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective loss of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). The events, which trigger and/or mediate the loss of nigral DA neurons, however, remain unclear. Neuroleptic-induced catalepsy has long been used as an animal model for screening drugs for Parkinsonism. Administration of haloperidol (1...

Increased Binding of Norepinephrine by Nerves to Cerebral Blood Vessels: Evidence from the Effects of Reserpine on Nerves to Cerebral and Extracerebral Blood Vessels • It has been proposed by others that adrenergic nerves to cerebral blood vessels bind norepinephrine more avidly than do nerves to vessels outside the brain. This suggestion is supported by the present data which show that in the ...

Reserpine has enhanced the cytotoxicity of 1 (4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2 chloroethyl)-3-nitrosourea hydrochloride (ACNU) in both ACNU-resistant sublines of C6 and 9L glioma cells (C6/ACNU, 9L/ACNU) and could completely overcome ACNU resistance in vitro. When reserpine was added to the culture in the concentration of 10ƒÊM, the concentrations of drug required for 50% inhibition ...