نتایج جستجو برای: resequencing

تعداد نتایج: 2156  

Journal: :Genetics 2011
Kirk E Lohmueller Carlos D Bustamante Andrew G Clark

We investigate the performance of tests of neutrality in admixed populations using plausible demographic models for African-American history as well as resequencing data from African and African-American populations. The analysis of both simulated and human resequencing data suggests that recent admixture does not result in an excess of false-positive results for neutrality tests based on the f...

2007
Gregory J Porreca Kun Zhang Jin Billy Li Bin Xie Derek Austin Sara L Vassallo Emily M LeProust Bill J Peck Christopher J Emig Fredrik Dahl Yuan Gao George M Church Jay Shendure

A new generation of technologies is poised to reduce DNA sequencing costs by several orders of magnitude. But our ability to fully leverage the power of these technologies is crippled by the absence of suitable ‘front-end’ methods for isolating complex subsets of a mammalian genome at a scale that matches the throughput at which these platforms will routinely operate. We show that targeting oli...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Fredrik Dahl Johan Stenberg Simon Fredriksson Katrina Welch Michael Zhang Mats Nilsson David Bicknell Walter F Bodmer Ronald W Davis Hanlee Ji

We have developed a procedure for massively parallel resequencing of multiple human genes by combining a highly multiplexed and target-specific amplification process with a high-throughput parallel sequencing technology. The amplification process is based on oligonucleotide constructs, called selectors, that guide the circularization of specific DNA target regions. Subsequently, the circularize...

2012
Takahito Ohshiro Kazuki Matsubara Makusu Tsutsui Masayuki Furuhashi Masateru Taniguchi Tomoji Kawai

Two paradigm shifts in DNA sequencing technologies-from bulk to single molecules and from optical to electrical detection-are expected to realize label-free, low-cost DNA sequencing that does not require PCR amplification. It will lead to development of high-throughput third-generation sequencing technologies for personalized medicine. Although nanopore devices have been proposed as third-gener...

Journal: :Nucleic Acids Research 2006
Fengxia Yao Ruifang Zhang Zanhua Zhu Kun Xia Chunyu Liu

In searching for susceptibility genes, both positional cloning and candidate gene strategies have been helpful. Mutation screening is one of the many technologies that have been implemented in order to identify mutations or polymorphisms in candidate genes or genomic regions. Since human genome sequence is available, PCR-direct sequencing is one of the major methods for mutation screening or re...

Journal: :Psychiatry and clinical neurosciences 2015
Emiko Inoue Yuichiro Watanabe Jingrui Xing Itaru Kushima Jun Egawa Shujiro Okuda Satoshi Hoya Takashi Okada Yota Uno Kanako Ishizuka Atsunori Sugimoto Hirofumi Igeta Ayako Nunokawa Toshiro Sugiyama Norio Ozaki Toshiyuki Someya

Rare variations contribute substantially to autism spectrum disorder (ASD) liability. We recently performed whole-exome sequencing in two families with affected siblings and then carried out a follow-up study and identified ceroid-lipofuscinosis neuronal 8 (epilepsy, progressive with mental retardation) (CLN8) as a potential genetic risk factor for ASD. To further investigate the role of CLN8 i...

Journal: :Genomics 2006
Wade P Smith Quyen Vu Shuying Sue Li John A Hansen Lue Ping Zhao Daniel E Geraghty

We carried out a resequencing project that examined 552 kb of sequence from each of 46 individual HLA haplotypes representing a diversity of HLA allele types, generating nearly 27 Mb of fully phased genomic sequence. Haplotype blocks were defined extending from telomeric of HLA-F to centromeric of HLA-DP including in total 5186 MHC SNPs. To investigate basic questions about the evolutionary ori...

Journal: :Human heredity 2010
Fang Han Wei Pan

Since associations between complex diseases and common variants are typically weak, and approaches to genotyping rare variants (e.g. by next-generation resequencing) multiply, there is an urgent demand to develop powerful association tests that are able to detect disease associations with both common and rare variants. In this article we present such a test. It is based on data-adaptive modific...

Journal: :International journal of systematic and evolutionary microbiology 2000
J Maréchal B Clement R Nalin C Gandon S Orso J H Cvejic M Bruneteau A Berry P Normand

The closer proximity of Frankia and Acidothermus cellulolyticus relative to the morphologically close Geodermatophilus found previously was confirmed by resequencing the rrs gene of Acidothermus cellulolyticus and the housekeeping gene, recA. The diagnostic sugar 2-O-methyl-D-mannose was detected only in Frankia, while hopanoid lipids were present at high levels in both Acidothermus and Frankia.

2011
Qingyou Xia

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