The replica exchange statistical temperature molecular dynamics (RESTMD) algorithm is presented, designed to alleviate an extensive increase of the number of replicas required as system size increases in the conventional temperature replica exchange method (tREM), and to obtain improved sampling in individual replicas. RESTMD optimally integrates multiple STMD (Phys. Rev. Lett. 2006, 97, 050601...

Metadata management is one of three major areas scientific data along with replica and workflow management. the information describing stored in a item, file or an object. It includes item provenance, recording conditions, format other attributes. MetaCat metadata database designed developed for High Energy Physics experiments. As component system, it’s main objectives are to provide efficient ...

In previous work, we have developed a simple method to study the behavior of the Sherrington-Kirkpatrick mean field spin glass model for high temperatures, or equivalently for high external fields. The basic idea was to couple two different replicas with a quadratic term, trying to push out the two replica overlap from its replica symmetric value. In the case of zero external field, our results...

The Low Latency Fault Tolerance (LLFT) system provides fault tolerance for distributed applications within a local-area network, using a leader-follower replication strategy. LLFT provides application-transparent replication, with strong replica consistency, for applications that involve multiple interacting processes or threads. Its novel system model enables LLFT to maintain a single consiste...

As the Internet continues to experience a tremendous expansion in number of users and services today, the importance of satisfying service availability becomes recently one of the most critical factors for the success of “Internet services” such as the World Wide Web, peer-to-peer file sharing and digital audio/video streaming. In this thesis, we take an availability-centric view on end-to-end ...

Screening or selection of mutants is an essential step in genetics. Mutants are invaluable tools for the elucidation of biochemical pathways, for defining the roles of genetic units in a particular pathway and for understanding the relationship between enzyme structure and function (3). For mutant searches, there are two approaches: (i) positive selection for mutants that can grow under selecti...

Here we review the approach to glassy systems based on the replica method and we introduce the main ingredients of replica symmetry breaking. We explain why the replica method has been successful in spin glass and why it should be successful for real glasses.