This clinical study, begun in 1975, tested the efficacy of early and delayed intensification treatments in children with acute lymphoblastic leukemia. Regardless of presenting features, all patients received 4 weeks of conventional induction therapy with daily prednisone and weekly vincristine and daunorubicin. Onethird were randomized to receive, in addition, two doses of asparaginase during i...

AIM To assess the endoscopic activity and Clinical activity after a one-year period of infliximab therapy and to evaluate the association between mucosal healing and need for retreatment after stopping infliximab in patients with Inflammatory bowel disease (IBD). METHODS The data from 109 patients with Crohn's disease (CD) and 107 patients with Ulcerative colitis (UC) received one-year inflix...

addiction to the illicit and prescribed use of opiate is an alarming public health issue. studies on addictive disorders have demonstrated severe nutritional deficiencies in opiate abusers with behavioral, physiological and cognitive symptoms. opiate addiction is also link with a significant number of diseases including human immunodeficiency virus (hiv), hepatitis c virus (hcv) and other blood...

We treated 109 patients with adult acute lymphoblastic leukemia (ALL) diagnosed by histochemical and immunologic techniques. Patients were excluded only for age greater than 50 years and Burkitt's leukemia. Treatment included a four-drug remission induction phase followed by alternating cycles of noncrossresistant chemotherapy and prolonged oral maintenance therapy. Eighty-eight percent of pati...

BACKGROUND Adalimumab is approved for use in patients with moderate to severe Crohn's disease (CD) or ulcerative colitis (UC) who have not achieved disease control with conventional therapies including corticosteroids and/or immunomodulators (IMM). AIM To analyse six studies that examined efficacy, pharmacokinetics and safety of combination IMM/adalimumab therapy, compared with adalimumab mon...

T he use of azathioprine or 6-mercaptopurine for maintaining remission in Crohn’s disease patients who are steroid dependent or resistant is unequivocally supported by evidence from randomised controlled clinical trials. The same, however, cannot be said for the use of immunomodulator therapy in ulcerative colitis (UC). Trials are scanty, small in size, conflicting in results, and clinical prac...

background: addiction to narcotics ‎can cause serious problems and ‎monetary losses. therapeutic ‎success can be predicted ‎through identifying lapse risk ‎factors.‎ objective: determining job risk ‎factor of lapse.‎ methods: this was a cross ‎sectional study on 351 addicts ‎visiting five methadone clinics. a ‎data collection sheet consisting ‎of questions on demographic ‎and job information wa...

Since the introduction of combined immunosuppressive therapy with oral cyclophosphamide (CYC) and glucocorticosteroids in the 1970s, the outcome of antineutrophil cytoplasmic antibody-associated vasculitides, for example, in granulomatosis with polyangiitis (Wegener`s), improved dramatically. However, the long-term follow-up of patients treated with CYC plus glucocorticosteroids has revealed hi...

Postpartum psychosis is a severe disorder that warrants acute clinical intervention. Little is known, however, about what interventions are most effective. The authors present treatment response and remission outcomes at 9 months postpartum using a four-step algorithm in patients with first-onset psychosis or mania in the postpartum period. Treatment involved the structured sequential administr...

IntroductionIn the Rituximab for Relapse Prevention in Nephrotic Syndrome (RITURNS) trial, we demonstrated superior efficacy of single-course rituximab over maintenance tacrolimus preventing relapses children with steroid dependent nephrotic syndrome (SDNS) during a 1-year observation. Here present long-term outcomes all 117 trial completers, who were followed up another 2 years.MethodsRelapsin...