Transmissible spongiform encephalopathies (TSEs or priori diseases) such as Creutzfeldt-Jakob disease and kuru in man or scrapie in sheep presented and still present major challenges to biomedical research. The first phase of investigation of these diseases was dominated by experiments at the biological level and led to the discovery of transmissibility, the existence of strains, as well as the...

With great interest, I have been observing the developments in continuous lifelong capture, which has been gaining momentum over the last few years. By lifelong capture, I refer to someone digitally logging every moment and element of their lives, a usually permanent recording of an activity by a participant in the activity. This process often results in the unanticipated capture of valuable mo...

The fields of language production and verbal memory have relatively little contact. I argue that utterance planning for language production has substantial memory maintenance demands and that utterance planning provides the maintenance and ordering processes for short-term verbal memory tasks. There has already been some movement toward this view. I discuss benefits to pursuing these links more...

Nonsteroidal anti-inflammatory drugs are in high demand. These agents are readily purchased without a prescription for headaches, fever, pain, and other common physical symptoms and complaints. The management of osteoarthritis and other chronic pain disorders, more often than not, involves a prescribed regimen of nonsteroidals among other analgesic and anti-inflammatory drugs. The combination o...

The highly prevalent neurodegenerative diseases Alzheimer’s (AD), Parkinson’s (PD), and Amyotrophic Lateral Sclerosis (ALS) have managed to elude countless efforts directed at understanding their causative agents and pathogenesis. Each of these diseases is characterized by abnormal protein aggregation under an unknown modi operandi we have determined to illuminate. AD pathology consists of neur...

Introduction Blustery Madrid winter days, traffic-congested streets and an encounter with dysfunctional public transport are difficult to forget. Fortunately, the approximately 50 scientists that gathered in the city for the workshop on ‘Memory and Related Disorders’ also took away memories of outstanding presentations and vigorous discussions. The workshop tackled a diverse set of topics inclu...