The problem with the practical application of decision-making regarding release of mentally ill defenders lies in the inherently ambiguous definitions of mental illness and dangerousness, both of which are necessary for the continued commitment of insanity acquittees. In this study, we examined how clinicians make release decisions in a forensic facility, with particular attention paid to how s...

This paper presents and evaluates an order release decision rule in a job-shop, based on the input-output control concept. The order release mechanism is part of a global decision-making scheme that includes four main decisions: accept/reject orders, define the order’s due date, release the accepted jobs and dispatch it on the shop floor. This paper also presents an evaluation of two acceptance...

BACKGROUND Patients with nocturnal hypertension are at higher risk for cardiovascular complications such as myocardial infarction and cerebrovascular insult. Published studies inconsistently reported decreases in nocturnal blood pressure with melatonin. METHODS A meta-analysis of the efficacy and safety of exogenous melatonin in ameliorating nocturnal blood pressure was performed using a rand...

Forty-one hands of 37 patients with idiopathic carpal tunnel syndrome treated by endoscopic carpal tunnel release (ECTR) were followed up for more than one year after surgery. Surgical results were evaluated using Kelly's criteria, the Semmes-Weinstein test, the static and moving 2-point discrimination tests, tip-pinch strength, and motor and sensory nerve conduction studies. Clinical results, ...

OBJECTIVE To investigate the effects of selective spinal anaesthesia with low-dose bupivacaine alone and in combination with various doses of fentanyl, on blockage, haemodynamics, quality of anaesthesia, perioperative complications, and hospital release criteria. METHODS This prospective study included 45 ASA I-II patients (age range: 20-77 years). The cases were randomised into 3 groups: Gro...

Translocation of primates is still a rare event. The translocation in 1984 of two research groups of wild baboons that had been studied for 12 years prior to translocation and observed for 18 years afterwards offers a comprehensive set of data with which to evaluate success. A comparison with indigenous baboon troops at the release site provides an independent control for assessing performance ...

Comparing modified-release formulations can be difficult using current bioequivalence criteria. Two 60-mg-once-daily nifedipine formulations are deemed bioequivalent in Canada. This study examined the validity of the assumption that these interchangeable, but different, delivery technologies are therapeutically equivalent in maintaining systolic blood pressure (SBP) control throughout the entir...

Recent observations from our laboratory have led us to hypothesize that d-opioid receptors may play a role in neuronal protection against hypoxic / ischemic or glutamate excitotocity. To test our hypothesis in this work, we used two independent methods, i.e., ‘‘same field quantification’’ of morphologic criteria and a biochemical assay of lactate dehydrogenase (LDH) release (an index of cellula...

Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration ...

background: the aim of this study was to directly compare efficacy of atomoxetine and methylphenidate in treatment of children and adolescents 6- 18 years.   methods: all published, randomized, open label or double blind trials, comparing the efficacy of methylphenidate with atomoxetine in treatment of children diagnosed with adhd, using dsm-iv criteria were included in this study; adhd rating ...