To evaluate whether the cervical sliding sign (CSS) can predict outcome of induction labour (IoL). Multicentre prospective study including singleton patients undergoing elective IoL by means oral Misoprostol 50 mcg 4 hourly for a maximum doses at ≥37 weeks gestation. On admission transvaginal ultrasound was performed prior to IoL. Maternal characteristics, length and presence CSS were recorded....

BACKGROUND Misoprostol is a new promising agent for cervical ripening and induction of labour .The ideal dose, route and frequency of administration of misoprostol are still under investigation. Although, vaginal application of misoprostol has been validated as a reasonable mean of induction, there is a patient resistance to digital examination and there is a risk of ascending infection. For th...

Misoprostol, a prostaglandin E1 analogue, is first used to prevent peptic ulcers. The FDA-approved indication in the product labelling for prevention and treatment of intestinal ulcer disease caused by use nonsteroidal anti-inflammatory medications. main advantages misoprostol include it's reasonably priced, compared other prostaglandins, it has modest effects on smooth muscle heart bronchial t...

in sheep industry, pregnancy rate after artificial insemination (ai) declines due to the complex anatomy of the cervix in ewes, such that it might prevent effective intrauterine insemination. at estrus, cervical relaxation occurs to some degree in ewes, which is regulated by the changes in the levels of reproductive hormones. this study aimed to evaluate the effects of estradiol and intravenous...

Background: Abortion is the medical or surgical termination of pregnancy before 20th week. However, dilation and curettage have been associated with hazards such as uterine rupture, heavy bleeding, infection. Therefore, in recent decades, pharmacological therapies become more widely accepted. Objectives: This research compared abortion success rates misoprostol/letrozole versus misoprostol/plac...

background: we sought to compare the effectiveness and safety of sublingual versus vaginal misoprostol for the termination of pregnancy with a live full-term fetus. methods: this randomized, triple-blind, placebo-controlled clinical trial was performed on 200 primiparous women with normal, singleton, full-term pregnancies candidated for the induction of labor. sublingual and vaginal tablets con...

BACKGROUND New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal. MATERIALS AND METHODS This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs. sublingual m...

BACKGROUND Misoprostol is widely used in obstetrics and gynaecology for medical abortion, cervical priming and induction of labour. To aid the design of effective and safe regimens, we have investigated the pharmacokinetic parameters after the vaginal or sublingual administration of repeated doses of 400 microg of misoprostol. METHODS Women undergoing termination of pregnancy by suction evacu...