This paper proposes to model protein regulation networks associated with severe acute respiratory syndrome (SARS) for early prediction of SARS. In the approach, specific to a patient group, a regulatory network is simulated using a fully-connected neural network and is optimized towards minimizing a novel energy function that is defined as a measure of disagreement between the input and output ...

We have combined the circular chromosome conformation capture protocol with high-throughput, genome-wide sequence analysis to characterize the cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10-1000 kb), the 4C approach provides a comprehensive, high-resolution analysis of a specific locus with the aim of defining, in detail, the...

Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators. In the past years, significant progress has been...

background and objectives: a single reactive igg anti-dengue virus elisa test in the absence of igm antibodies or ns1 antigen may denote current infection or past exposure to the virus. to determine whether igg index value can be used to identify true current dengue infection we conducted a prospective observational study. materials and methods: suspected dengue patients (n =1745) were tested i...

Coupling chromosome conformation capture to molecular enrichment for promoter-containing DNA fragments enables the systematic mapping of interactions between individual distal regulatory sequences and their target genes. In this Minireview, we describe recent progress in the application of this technique and related complementary approaches to gain insight into the lineage- and cell-type-specif...

Major multi-protein photosynthetic complexes, located in thylakoid membranes, are responsible for the capture of light and its conversion into chemical energy in oxygenic photosynthetic organisms. Although the structures and functions of these photosynthetic complexes have been explored, the molecular mechanisms underlying their assembly remain elusive. In this review, we summarize current know...

We have combined the circular chromosome conformation capture protocol with high-throughput, genome-wide sequence analysis to characterize the cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting regions (10–1000 kb), the 4C approach provides a comprehensive, high-resolution analysis of a specific locus with the aim of defining, in detail, the...

When policy arrangements appear to favor well-organized and wealthy interests, should we infer “capture” of the political process? In particular, might larger firms receive regulatory “protection” even when the regulatory agency is not captured by producers? I model regulatory approval—–product approval, licensing, permitting and grant making—–as a repeated optimal stopping problem faced by a l...

The carcinogenicity (cancer-inducing potential) of pharmaceuticals is an important risk factor for health when considering whether thousands of patients on drug trials or millions/billions of consumers in the marketplace should be exposed to a new drug. Drawing on fieldwork involving over 50 interviews and documentary research spanning 2002-2010 in Europe and the US, and on regulatory capture t...