Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (Valporic acid, ATRA) are being investigated as potential treatments for the population of refractory cases of AML. Herein, we repo...

introduction application of near-infrared absorbing nanostructures can induce hyperthermia, in addition to providing more efficient  photothermal effects. gold-gold sulfide (ggs) is considered as one of these nanostructures. this study was performed on a tissue-equivalent optical-thermal phantom to determine the temperature profile in the presence and absence of ggs and millisecond pulses of a ...

introduction: refractory status epilepticus is a life-threatening disease in children wherein seizure movements don't response to first line anti convulsion drugs. this study reviewed risk factors, management and early outcome of children with refractory status epilepticus. methods: patients with refractory status epilepticus admitted in tabriz children's hospital between 2003 and 200...

lamotrigine (ltg), a newly developed antiepileptic drug (aed), is efficacious in treating refractory epilepsy. this study was designed to evaluate the efficacy and safety of ltg as add-on therapy in 40 children with refractory epilepsy. the trial was an open-labeled prospective study in children with drug-resistant epilepsy aged <14 years, who had at least 4 seizures per month in spite of recei...

epilepsy is a neurological disease of the central nervous system. it is estimated that about 50-70 million people worldwide suffer from this chronic disorder and 20 to 30% are resistant to conventional anti-epileptic drugs. in the epilepsy therapeutic arena, there is real need for developing novel antiepileptogenesis treatments that offer a way to prevent the onset or the progression of the dis...

Refractory materials exhibit high damage tolerance, which is attractive for the creation of nanoscale field-emission electronics and optoelectronics applications that require operation at peak current densities optical intensities. Recent results have demonstrated properties titanium nitride, a refractory CMOS-compatible plasmonic material, can be tuned by adding silicon oxygen dopants. However...

biotin is a water-soluble vitamin and co-factor for activation of carboxylases apoenzymes. biotinidase enzyme is essential for release of biotin from apoenzymes. absence of biotinidase is an autosomal recessive trait with a prevalence of 1 in 60000. clinical manifestations of biotinidase deficiency include dermatitis, alopecia, seizures, hypotonia, developmental delay, hearing loss, visual impa...

background: patients with gastroesophageal reflux disease (gerd) unresponsive to proton pump inhibitor (ppi) therapy are often labeled as having refractory gerd. one of the probable etiologies of refractory gerd is delayed gastric emptying. refractory gerd associated with gastroparesis is a complex condition with no definitive treatment to date. we opted, for the first time, to test the hypothe...