Organizations have found that functional approach to business destroys flexibility and agility by gaining experience over the time. The main weakness with Task-based organizations is that they can hardly act flexibly and adapt themselves to the changing environment. In today’s' dynamic and competitive business world, organizations focus significantly on managing and improving their business pro...

Context: Software Reference Architectures (SRAs) play a fundamental role for organizations whose business greatly depends on the efficient development and maintenance of complex software applications. However, little is known about the real value and risks associated with SRAs in industrial practice. Objective: To investigate the current industrial practice of SRAs in a single company from the ...

The advent of affordable Next Generation Sequencing technologies has had major impact on studies of many crop species, where access to genomic technologies and genome-scale data sets has been extremely limited until now. The recent development of genomic resources in blueberry will enable the application of high throughput gene expression approaches that should relatively quickly increase our u...

Cowden's syndrome is a rare genodermatosis characterized by multiple hamartomas in several tissues and organs derived from all three embryonic layers. Clinical features of Cowden's disease are explained by the mutation of the PTEN tumour suppressor gene, whose modification leads to an uncoordinated growth of tissues. The importance of this disease lies in the increased susceptibility to maligni...

Galactosaemia was originally described by von Reuss in 1908 and since then a number of cases have been reported. From a study of these a fairly characteristic picture is presented, the most constant features being failure to thrive, hepatomegaly, galactosua and albuminuria. Other less constant features are mental retardation, jaundice, vomiting, cataract, pyrexia, diarrhoea and a tendency to bl...

The result of a domain maturing is the emergence of reference architectures that offer numerous advantages to software architects and other stakeholders. However there is no straightforward way to describe a reference architecture and in sequence to design instances for specific systems, while at the same time assuring the quality of the end product. This paper presents an approach of describin...