We present a detailed study of the mechanism for oxidative heteroarylation, based on DFT calculations and experimental observations. We propose binuclear Au(II)-Au(II) complexes to be key intermediates in the mechanism for gold catalyzed oxidative heteroarylation. The reaction is thought to proceed via a gold redox cycle involving initial oxidation of Au(I) to binuclear Au(II)-Au(II) complexes ...

The mitochondrial amidoxime reducing component mARC is the fourth mammalian molybdenum enzyme. The protein is capable of reducing N-oxygenated structures, but requires cytochrome b5 and cytochrome b5 reductase for electron transfer to catalyze such reactions. It is well accepted that the enzyme is involved in N-reductive drug metabolism such as the activation of amidoxime prodrugs. However, the...

Let EG be a stable principal G–bundle over a compact connected Kähler manifold, where G is a connected reductive linear algebraic group defined over C. Let H ⊂ G be a complex reductive subgroup which is not necessarily connected, and let EH ⊂ EG be a holomorphic reduction of structure group. We prove that EH is preserved by the Einstein–Hermitian connection on EG. Using this we show that if EH ...

The interaction of acridine orange (AO) with heparin was studied by voltammetric method. In Britton-Robinson (B-R) buffer solution (pH 2.3), AO showed a sensitive linear sweep voltammetric reductive peak at -0.94 V (vs. SCE). The addition of heparin into the AO solution caused a decrease in the reductive peak current without any change in the peak potential. The results indicated that a reactio...

Kobayashi (Duke Math. J. 67:653–664, 1992) gave a necessary condition for the existence of compact Clifford–Klein forms in terms Cartan projections and non-compact dimensions reductive subgroups. We extend his method to non-reductive subgroups give some examples homogeneous spaces type that do not admit by comparing with those

Explanatory pluralism is the view that the best form and level of explanation depends on the kind of question one seeks to answer by the explanation, and that in order to answer all questions in the best way possible, we need more than one form and level of explanation. In the first part of this article, we argue that explanatory pluralism holds for the medical sciences, at least in theory. How...

Based on 16S rRNA gene surveys, bacteria of the epsilon subdivision of proteobacteria have been identified to be important members of microbial communities in a variety of environments, and quite a few have been demonstrated to grow autotrophically. However, no information exists on what pathway of autotrophic carbon fixation these bacteria might use. In this study, Thiomicrospira denitrificans...

We study linear actions of algebraic groups on smooth projective varieties X. A guiding goal for us is to understand the cohomology of “quotients” under such actions, by generalizing (from reductive to non-reductive group actions) existing methods involving Mumford’s geometric invariant theory (GIT). We concentrate on actions of unipotent groups H, and define sets of stable points X and semista...