The Intergovernmental Panel on Climate Change (IPCC) has successfully produced four assessment reports since 1990 along with a number of special reports and greenhouse gas inventory guidelines. It has very rigorous and robust procedures and guidelines for preparing the assessment reports largely based on synthesis of peer-reviewed and published scientific literature. IPCC has attracted controve...

Although a substantial part of scientific research is collaborative and increasing globalization will probably lead to its increase, very few studies actually investigate the advantages, disadvantages, experiences and lessons learned from collaboration. In environmental epidemiology interdisciplinary collaboration is essential and the contrasting geographical patterns in exposure and disease ma...

Ever since Rick Shull asked me to prepare an essay of appreciation of Fred Keller, I have found myself putting it off. Somehow, something else was always needing to be done. Finally, I realized what was happening. I just did not want to face the fact that Fred was no longer with us. After a relationship that extended over more than 50 years, during which Fred taught me both pedagogically and by...

In a service environment a service provider needs to determine the amount and kinds of capacity to meet customers’ needs over many periods. To make good decisions, she needs to know the probability distribution of her customers’ demand in each period. We study a situation in which customers’ demand for a given service is random in each period, but inelastic, or modeled well by this assumption, ...

In this review we briefly describe the development of CRISPR tools for genome editing and control of transcription in bacteria. We focus on the Type II CRISPR/Cas9 system, provide specific examples for use of the system, and highlight the advantages and disadvantages of CRISPR versus other techniques. We suggest potential strategies for combining CRISPR tools with high-throughput approaches to ...

The prevalence of burnout is higher in physicians than in other professions and is especially high in neurologists. Physician burnout encompasses 3 domains: (1) emotional exhaustion: the loss of interest and enthusiasm for practice; (2) depersonalization: a poor attitude with cynicism and treating patients as objects; and (3) career dissatisfaction: a diminished sense of personal accomplishment...