This study examined the clinical and biological importance of thioredoxin-1, a redox-active defensive protein that controls multiple biological functions, in pregnant women. We measured serum concentrations of thioredoxin-1, total hydroperoxides, and redox potential in 60 pregnant women at the early third trimester: gestational age of 27-29 weeks. The thioredoxin-1 concentration (mean ± SD) was...

Hydrogen peroxide (H2O2) controls signaling pathways in cells by oxidative modulation of the activity of redox sensitive proteins denominated redox switches. Here, quantitative biology concepts are applied to review how H2O2 fulfills a key role in information transmission. Equations described lay the foundation of H2O2 signaling, give new insights on H2O2 signaling mechanisms, and help to learn...

0a thin film of cobalt hexacyanoferrate (cohcf), an analogue of mixed-valence prussian blue, was deposited electrochemically on the glassy carbon, platinum and gold electrode surfaces in 0.5m kc1 solution. the electrochemical behavior of these modified electrodes show three couples of redox peaks by cv in a supporting electrolyte solution of 0.5m nacl, whereas for au modified electrode only one...

ni6(n2h4)6(so4)4(oh)2(h2o)8](so4)(h2o)10 complex was prepared according to literature report. the reaction between aforementioned complex via sodium alkoxides as a reactants, were carried out in the solid state. the [ni6(n2h4)6(so4)4(oh)2(h2o)8](so4)(h2o)10 undergoes an intramolecular two electrons oxidation-reduction reaction at room temperature and metallic nickel nanoparticles (ni1-ni5) was ...

ni6(n2h4)6(so4)4(oh)2(h2o)8](so4)(h2o)10 complex was prepared according to literature report. the reaction between aforementioned complex via sodium alkoxides as a reactants, were carried out in the solid state. the [ni6(n2h4)6(so4)4(oh)2(h2o)8](so4)(h2o)10 undergoes an intramolecular two electrons oxidation-reduction reaction at room temperature and metallic nickel nanoparticles (ni1-ni5) was ...

Redox-sensitive GFPs with engineered disulphide bonds have been used previously to monitor redox status in the cytosol and mitochondria of living cells. The usefulness of these redox probes depends on the reduction potential of the disulphide, with low values suiting the cytosol and mitochondrion, and higher values suiting the more oxidising environment of the endoplasmic reticulum (ER). Here, ...

Previous research shows that stimulation of proliferation of colon carcinoma (Caco-2) cells by a more reduced extracellular cysteine/cystine (Cys/CySS) redox state occurs with no apparent effect on intracellular glutathione and that this stimulation is lost on addition of epidermal growth factor. The purpose of the present study was to determine whether a more reduced extracellular Cys/CySS red...

BACKGROUND Targeting cancer cell metabolism is recognized as a promising arena for development of cancer chemotherapeutics. Moreover, redox metabolism is also systematically altered in tumor cells. Indeed, there is growing reason to believe that tumor-specific alteration of redox control of metabolism will be central to understanding and attacking malignancy. We report here that lipoate analog ...

This review focuses on thiol/disulfide redox switches that regulate heme binding to proteins and modulate their activities. The importance of redox switches in metabolic regulation and the general mechanism by which redox switches modulate activity are discussed. Methods are described to characterize heme-binding sites and to assess their physiological relevance. For thiol/disulfide interconver...

Life and element cycling on Earth is directly related to electron transfer (or redox) reactions. An understanding of biogeochemical redox processes is crucial for predicting and protecting environmental health and can provide new opportunities for engineered remediation strategies. Energy can be released and stored by means of redox reactions via the oxidation of labile organic carbon or inorga...