Introduction: Estrogen, a crucial hormone during pregnancy, acts through two types of receptors. The estrogen receptor alpha and beta (ESR-α and ESR-β) are more abundant and exists in all human reproductive systems. Association of ESR-α and ESR-β genes polymorphisms has been reported in some reproductive problems such as spontaneous abortion, endometriosis-related infertility, and in vitro fert...

By selecting chromosomally normal embryos for replacement, PGD for aneuploidy can (i) increase implantation rates, (ii) reduce spontaneous abortion rates, and (iii) avoid aneuploid conceptions. When eight chromosomes are analysed, a significant increase in implantation is achieved. PGD is also found to significantly reduce the incidence of spontaneous abortion and chromosomally abnormal concept...

Background Effects of GCSF (Granulocyte Colony-stimulating Factor) injection in patients suffering from recurrent pregnancy loss has been studied in some studies and we now know that transvaginal perfusion of G-CSF might be helpful for improvement of implantation rate among patients with thin endometrium and patients under in vitro fertilization /embryo transfer (IVF/ET) or intracytoplasmic spe...

Pregnancy loss can be caused by several factors involved in human reproduction. Although up to 50% of cases remain unexplained, it has been postulated that the major cause of failed pregnancy is an error of embryo implantation. Transmembrane mucin-1 (MUC-1) is a glycoprotein expressed on the endometrial cell surface which acts as a barrier to implantation. The gene that codes for this molecule ...

Background: Repeated Implantation Failure (RIF) is one of the most intricate obstacles in assisted reproduction. The cytokine and chemokine composition of uterine cavity seem to play important roles in the implantation process. Objective: To compare the cytokine profile in the endometrium of normal fertile women and those with repeated implantation failure. Methods: After enzymatic digestion of...