BACKGROUND Combined radiotherapy and hyperthermia is a well-established alternative to chemoradiotherapy for advanced stage cervical cancer patients with a contraindication for chemotherapy. Pre-clinical evidence suggests that the radiosensitizing effect of hyperthermia decreases substantially for time intervals between radiotherapy and hyperthermia as short as 1-2 h, but clinical evidence is l...

BACKGROUND The Medicare program provides universal access to hospital care for the elderly; however, mortality disparities may still persist in this population. The association of individual education and area income with survival and recurrence post Myocardial Infarction (MI) was assessed in a national sample. METHODS Individual level education from the National Longitudinal Mortality Study ...

We are reporting on a colorectal cancer patient with the longest disease-free interval ever published, where chromosomal microarray analysis was used to confirm the link between the primary and metastatic lesions. This rare case reports on a patient with late recurrence of colorectal cancer in the lung 19 years after its initial diagnosis. We used high-resolution array CGH (aCGH) to analyze the...

A reactive system does not terminate and its behaviors are typically defined as a set of infinite sequences of states. In formal verification, a requirement is usually expressed in a logic, and when the models of the logic are also defined as infinite sequences, such as the case for LTL, the satisfaction relation is simply defined by the containment between the set of system behaviors and that ...

Background: The conventional method of repair of anterior urethral stricture with dilatation and Visual Internal Urethrotomy (VIU) resulted in high recurrence. Hence buccal mucosa is used for long term stricture free interval and is an effective measure of preventing stricture recurrence. Objectives: 1) To determine the presentation, aetiology, age distribution and associated symptoms of anteri...

BACKGROUND AND PURPOSE The integrity of white matter tracts connecting different parts of the brain is important for rapid compensation for the lost function from ischemic stroke. Impaired white matter reserve capacity secondary to leukoaraiosis may facilitate detection of new symptomatic ischemic events that would otherwise remain inconspicuous after an initial ischemic stroke. We sought to id...

Let {α1, α2, . . . } be a sequence of real numbers outside the interval [−1, 1] and μ a positive bounded Borel measure on this interval. We introduce rational functions φn(x) with poles {α1, . . . , αn} orthogonal on [−1, 1] and establish some ratio asymptotics for these orthogonal rational functions, i.e. we discuss the convergence of φn+1(x)/φn(x) as n tends to infinity under certain assumpti...

BACKGROUND Due to early colonoscopy for some participants, interval-censored observations can be introduced into the data of a colorectal polyp prevention trial. The censoring could be dependent of risk of recurrence if the reasons of having early colonoscopy are associated with recurrence. This can complicate estimation of the recurrence rate. METHODS We propose to use midpoint imputation to...

BACKGROUND: Breast cancer represents the leading form of invasive cancer among American women, killing nearly 50,000 annually. Several prognostic factors that are associated with survival include age, race, menopausal status, and the stage of disease at presentation. METHODS: Patient characteristics were collected based on a systematic chart audit of demographic features and medical, family, an...

Autologous formalin-fixed tumor vaccine (AFTV) suppressed re-recurrence for more than 32 months of multiple-recurrent hepatocellular carcinoma based on hepatitis C virus-induced liver cirrhosis in a case with previous recurrence interval, 51-, 28-, 12-, and 4-months. We detected glypican-3-specific cytotoxic T lymphocytes in the peripheral blood at 12 months after AFTV.