background: staphylococcus aureus (s. aureus) is a major nosocomial pathogen and the infection with this organism in human is increasing due to the spread of antibiotic resistant strains. one of the resistance mechanisms of s. aureus comprises modification in binding proteins to penicillin. vaccine strategy may be useful in controlling the infections induced by this organism. this study aimed a...

there are more than 350 million individuals with hepatitis c in the world. one of the important problems in vaccine project is development of effective and suitable adjuvant in human vaccines. at present research we applied human βhsp90 protein as an adjuvant in recombinant hcv vaccine design. the thermal vector of pgp1-2 was used for human heat shock protein 90 expression. this protein injecte...

abstract background and aims: influenza a(h5n1) viruses  circulating in animals might evolve and acquire the ability to spread from  human to human and thus start a pandemic. hemagglutinin (ha) has been shown to play a major role in binding of influenza virus to its target cell and the main neutralizing antibody responses elicit against this region. recent studies have shown that glycosylation ...

background and aims: influenza a(h5n1) viruses  circulating in animals might evolve and acquire the ability to spread from  human to human and thus start a pandemic. hemagglutinin (ha) has been shown to play a major role in binding of influenza virus to its target cell and the main neutralizing antibody responses elicit against this region. recent studies have shown that glycosylation of ha is ...

Human interferon-gamma (hIFNγ) is an important pleiotropic cytokine with therapeutic application. Recombinant hIFNγ has been shown to be effective pharmaceutical against a wide range of viral, immuno-suppressive diseases promising prospects in cancer immunotherapy resulting strong increase demand and price. The aim this study was develop efficient method for production soluble active hIFNγ. To ...

objective: angiogenesis a process that results in neo-vascularization is an essential stage in growth of solid tumors and the formation of metastases. vascular endothelial growth factor (vegf) and its receptors, vegfr1 (flt-1) and vegfr2 (kdr/flk-1), are the major regulators for tumor angiogenesis. recent studies showed that second domain of vegfr-1is a key factor for vegf/vegfr-1 interaction. ...

Hek-293 cell line presents good production platform for recombinant therapeutic proteins, however little is known about the components that contribute to the cellular control of recombinant protein production. In this study, we generated a Hek-293 producing recombinant factor VIII (FVIII) and we evaluated the immunoglobulin-binding protein (BiP) and phytanoil-CoA α-hydroxylase (PAHX) expression...

Human SP-D is a potent innate immune molecule whose presence at pulmonary mucosal surfaces allows its role in surveillance against pathogens. Higher levels of serum have been reported the patients with severe acute respiratory syndrome coronavirus (SARS-CoV). Studies suggested ability human to recognise spike glycoprotein SARS-CoV; interaction HCoV-229E strain leads viral inhibition bronchial e...