objective: escherichia coli o157:h7 is a gram-negative rod-shaped bacterium. e coli o157:h7 is an enterohemorrhagic (ehec) strain of the bacterium escherichia coli and a cause of foodborne illness. infection often leads to bloody diarrhea by producing a toxin called shiga toxin, which damages the intestines, and occasionally leads to kidney failure, especially in young children and elderly peop...

background and objectives: brucellosis is an important health problem in developing countries and no vaccine is available for the prevention of infection in humans. because of clinically infectious diseases and their economic consequences in human and animals, designing a proper vaccine against brucella is desirable. in this study, we evaluated the immune responses induced by a designed recombi...

important thermodynamic parameters including denaturant equilibrium m values (meq) and heat capacity changes (δcp) can be predicted based on changes in solvent accessible surface area (sasa) upon unfolding. crosslinks such as disulfide bonds influence the stability of the proteins by decreasing the entropy gain as well as reduction of sasa of unfolded state. the aim of the study was to develop ...

objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

Chlamydia trachomatis is one of the main causes of Sexually Transmitted Diseases (STDs) such as  prostatitis and epididymitis in men and cervicitis, endometriosis, vaginitis and ureogenital tract infections in women.  Serological tests with sensitivities related to specific antigens are commonly used as  routine laboratory tests for diagnosis of Chlamydia. In this research the Chlamydia Major O...