The expression of adrenomedullin (ADM) in injured tissue of rat spinal cord was observed and the effect of recombinant human erythropoietin was analyzed. A total of 45 Sprague-Dawley rats were selected and divided into 3 equal groups including, a sham-operation group in which rats received an excision of vertebral plate; a spinal cord injury model group and a recombinant human erythropoietin gr...

Human recombinant erythropoietin is a synthetic hormone for treatment of some kinds of anemia. In this study, the effect of this hormone was investigated on blood cell changes in adult and immature rats. For this purpose, the hormone was administered at doses of 50, 100, and 200 IU/Kg (s.c.) twice a week for a period of 6 weeks. Then, the number of red blood cells (RBC), subtypes of white blood...

Recombinant human erythropoietin produced in transfected Chinese hamster ovary cells is glycosylated much the same way as the erythropoietin present in human urine. To determine the role of carbohydrates in the stability of recombinant human erythropoietin in vivo, [125I]-labeled recombinant erythropoietin was intravenously infused into rats. The erythropoietin was slowly cleared from the blood...

Prof. Dr. Kuddusi Cengiz, Ondokuz Mayis University School of Medicine, Department of Nephrology, TR-55139 Samsun (Turkey) Dear Sir, The correction of anemia in hemodialysis patients with human recombinant erythropoietin increases appetite, anabolic effects, and improves physical, psychological activities and endocrine functions. As the sense of well-being improves, the patients increase food in...

The role of the kidney in foetal erythropoiesis was studied in newborn SD mice on the day of birth. Some of the homozygotes and heterozygotes of this strain are born anephric. Red cell production was evaluated by haematocrit levels, reticulocyte counts, and Fe-uptake in liver and RBC, the isotope given to the mothers during pregnancy. Erythropoiesis of the newborn with renal agenesis was not di...

Human recombinant erythropoietin (epoetin) is a very effective and safe biopharmaceutical. However, in 1998 the incidence of pure red cell aplasia (PRCA) induced by antierythropoietin (anti-EPO) antibodies in patients treated with epoetin started to increase. PRCA is a rare condition of non-regenerative anemia which can be associated with a variety of diseases and is in some cases of immunologi...

The role of the kidney in foetal erythropoiesis was studied in newborn SD mice on the day of birth. Some of the homozygotes and heterozygotes of this strain are born anephric. Red cell production was evaluated by haematocrit levels, reticulocyte counts, and Fe-uptake in liver and RBC, the isotope given to the mothers during pregnancy. Erythropoiesis of the newborn with renal agenesis was not di...