Kremen 1 and 2 (Krm1/2) are transmembrane receptors for Wnt antagonists of the Dickkopf (Dkk) family and function by inhibiting the Wnt co-receptors LRP5/6. Here we show that Krm2 functions independently from Dkks during neural crest (NC) induction in Xenopus. Krm2 is co-expressed with, and regulated by, canonical Wnts. Krm2 is differentially expressed in the NC, and morpholino-mediated Krm2 kn...

Breast cancer (BC) is one of the most widespread types affecting females, and therefore, early diagnosis critical. BC a complex heterogeneous disease affected by several key pathways. Among these, WNT proteins their frizzled receptors (FZD) have been demonstrated to be crucial in regulating number cellular molecular events tumorigenesis. The role receptor, FZD8, has received minimal attention; ...

Protein tyrosine kinase 7 (PTK7) is an evolutionarily conserved transmembrane receptor with important roles in embryonic development and disease. Originally identified as a gene upregulated in colon cancer, it was later shown to regulate planar cell polarity (PCP) and directional cell movement. PTK7 is a Wnt co-receptor; however, its role in Wnt signaling remains controversial. Here, we find ev...

Wnt signalling is an important component of vertebrate development, required for specification of the neural crest. Ten Wnt receptors [Frizzled receptor 1-10 (Fzd1-10)] have been identified so far, some of which are expressed in the developing nervous system and the neural crest. Here we show that expression of one such receptors, Fzd6, predicts poor survival in neuroblastoma patients and marks...

BACKGROUND While kidney injury is associated with re-expression of numerous Wnt ligands and receptors, molecular mechanisms which underlie regulation of distinct Wnt signaling pathways and ensuing biological consequences remain incompletely understood. Primary cilia are increasingly being recognized as cellular 'antennae' which sense and transduce signals from the microenvironment, particularly...

background: dysregulation of wnt signaling has been reported in many malignancies. objective: this study was conducted to investigate the expression pattern of 14 members of the wnt gene family in different immunophenotypic subtypes of all. methods: semi-quantitative rt-pcr was performed on samples from 71 all patients and 36 age-matched healthy individuals. the all patients were categorized in...

Solar lentigo (SL) is a common hyperpigmented lesion occurring on sun-exposed skin, and sign of photodamage aging. WNT/β-catenin signaling promotes melanogenesis via activating MITF, the master regulator melanocytes. Secreted frizzled related proteins (sFRP) are antagonists that inhibit binding WNT ligands to their receptors. However, recent studies have reported sFRP2 activates melanocytes, su...

Convincing evidence has accumulated to identify the Frizzled proteins as receptors for the Wnt growth factors. In parallel, a number of secreted frizzled-like proteins with a conserved N-terminal frizzled motif have been identified. One of these proteins, Frzb-1, binds Wnt-1 and Xwnt-8 proteins and antagonizes Xwnt-8 signaling in Xenopus embryos. Here we report that Frzb-1 blocks Wnt-1 induced ...

All signaling pathways have their complexities , but Wnt signaling may be more complex than most. There are 19 different Wnt ligands in mammals that bind to multiple types of receptors, some of which activate a canonical pathway that stabilizes the tran-scriptional coactivator ␤-catenin, and some of which signal via noncanonical, ␤-catenin– independent pathways. Roarty et al. begin to unpick th...