Macroscopic sampling of multiple sclerosis lesions in the brain tends to find chronic lesions. For a better understanding of the dynamics of the multiple sclerosis disease process, research into new and developing lesions is of great interest. As MRI in vivo effectively demonstrates lesions in multiple sclerosis patients, we have applied it to unfixed post-mortem brain slices to identify abnorm...

PURPOSE To report the clinicopathologic features and management of patients with benign reactive lymphoid hyperplasia of the caruncle and plica semilunaris. METHODS This retrospective case series includes 5 patients with lesions in the caruncle or plica semilunaris who underwent surgical excision over a 10-year period. The clinicopathologic features and immunohistochemical studies are reporte...

OBJECTIVES To present and discuss 2 patients with acquired peripapillary pigmented lesions. METHODS We reviewed the patients' clinical records and histopathologic findings. RESULTS The first patient was diagnosed with a pigmented papillary lesion that was followed up for 38 years. The second patient was a child with neurofibromatosis type 1 who developed a pigmented peripapillary lesion fol...

Background: To evaluate the association between pre/post-procedural high sensitive C-reactive protein (hs-CRP) level and hs-CRP difference, and the risk of major adverse cardiovascular events (MACE) or new diffusion-weighted MRI lesions after carotid angioplasty and stenting (CAS). Methods: In this study, conducted in 2016 in Shiraz (Iran), patients who underwent diagnostic angiography and CAS...

Oligodendrocyte progenitor cells (OPCs) can repair demyelinated lesions by maturing into myelin-producing oligodendrocytes. However, the OPC potential to differentiate can be prevented by inhibitory signals present in the pathological lesion environment. Identification of these signals is essential to promote OPC differentiation and lesion repair. We identified an endogenous inhibitor of remyel...

the histopathologic diagnosis of orbital and ocular adnexal lymphoproliferative lesions is difficult, resulting controversy in classification, determining benignity or malignancy of them and treatment modality selection. we designed the following study to evaluate clinical, histopathologic and if necessary immunochemical features of them in decreasing indeterminate cases. the study includes 51 ...

background: the role of retinoblastoma (rb) protein in cell cycle regulation prompted us to take up this study with the aim of assessing its role in the progression of oral cancer and to correlate with various clinicopathological parameters, including habits such as smoking, paan chewing, and alcoholism. materials and methods: this observational study included surgical specimens from 10 apparen...

introduction: giant cell lesions of the bone comprise a group of jaw bone pathologies. different pathogeneses such as reactive, vascular or neoplastic have been proposed for these lesions. in addition, differentiating between aggressive and nonaggressive central giant cell granuloma (cgcg) of the jaws based on histopathologic features is still impossible and due to different treatment protocols...

Surgical repair of a Bankart lesion requires thorough recognition of the capsulolabral attachment and adequate visualization for suture anchor repair. The glenoid labrum usually detaches from its capsule and bony attachment anteriorly and inferiorly; however, the labral and capsule detachment can sometimes extend beyond this zone of injury. Identification and repair may require additional viewi...