Abstract Asexual reproduction by fissiparity has only been described from very few of the approximately 1300 nemertean species that otherwise mainly reproduce sexually. The best studied fissiparous species, Lineus sanguineus (Rathke 1799), is a cosmopolitan heteronemertean inhabiting intertidal habitats temperate coasts. Although sexual never described, molecular data suggest substantially shap...

A retrospective review was performed on 11 patients who had undergone the transcolumellar transsphenoidal hypophysectomy in our center. There were eight females and three males with age ranging from 17 to 72 years (mean 50 years). Ten patients had pituitary macroadenomas and one had suprasellar cyst. The mean follow up duration for these 11 patients post surgery was 7.2 months. Complications in...

Rosai-Dorfman disease (RDD) is a rare, idiopathic, benign histioproliferative disorder. Extranodal involvement is seen in around 25-40% of patients. Central nervous system manifestation of RDD is uncommon and suprasellar location of the lesion is a distinct rarity. Surgery is the cornerstone of management of intracranial RDD. However, tumor recurrence or regrowth is a potential problem. Hence, ...

BACKGROUND There are many countries in the world where patients with cleft lip and palate cannot get access to specialized cleft care units. Cleft missions play an important role in providing surgical care to the areas of the world with limited resources. This article presents a model of cleft missions that can be adopted in many countries where expertise is available but resources are limited....

Sex-determining region Y (SRY) box 2 (SOX2) haploinsufficiency causes a form of hypopituitarism in humans that is characterized by gonadotrophin deficiency known as hypogonadotrophic hypogonadism. Here, we conditionally deleted Sox2 in mice to investigate the pathogenesis of hypogonadotrophic hypogonadism. First, we found that absence of SOX2 in the developing Rathke pouch of conditional embryo...

Childhood craniopharyngiomas are rare embryogenic malformations of the sellar region, presumably derived from Rathke cleft epithelium. The overall survival rates after neurosurgical intervention and/or irradiation are high (92%). However, the quality of survival is frequently impaired due to endocrine deficiencies, sleep disturbances, daytime sleepiness, and severe obesity caused by hypothalami...

In summer, high temperatures are combined w ~ t h severe nocturnal hypoxia In the shallow water of Danish fjords. Under these conditions, the prawns Palaemonetes varians (Leach) and Palaem o n adspersus (Rathke) are spatially separated, with the former occupying the areas of highest temperature and lowest oxygen tension. If kept together, P, adspersus shows aggressive behavlour towards P varian...

A 6-year old patient presented with an intra and suprasellar cystic lesion accompanied with impairment of the hypothalamic-pituitary axis and partial hypopituitarism. The most likely cause of sellar lesions in this age group are adamantinomatous craniopharyngioma (adaCP) or Rathke´s cleft cysts (RCCs). AdaCP are characterized by CTNNB1 mutations accompanied with aberrant nuclear beta-catenin ex...

Pitx2 is a homeodomain transcription factor that is mutated in Rieger syndrome, a haploinsufficiency disorder affecting eyes and teeth. Pitx2 also has a postulated role in left-right axis determination. We assessed the requirements for Pitx2 directly by generating hypomorphic and null alleles. Heterozygotes for either allele have eye abnormalities consistent with Rieger syndrome. The ventral bo...

PURPOSE To determine the value of inversion recovery half-Fourier single-shot turbo spin-echo (IR-HASTE) MR sequences in the characterization of a variety of intracranial lesions, with the focus on differentiating between epidermoids and nonneoplastic cystic lesions. METHODS We used a 1.5-T MR unit to study five epidermoids, seven arachnoid cysts, seven other nonneoplastic cysts (three neuroe...