The healing effect of heparin on gastric ulcer and its underlying mechanisms were studied. The influences of protamine on these effects were also investigated. Gastric ulcer was induced by acetic acid in rats. Heparin (100-1000 U/kg i.v.) was given once daily for 4 or 7 days. Ulcer area was measured; gastric mucosal regeneration, proliferation, and angiogenesis were determined by histological o...

Water, methanol and chloroform extracts of Landolphia owarensis were investigated for their effects on gastric acid secretion and ulceration in male albino rats. Two models of gastric lesion induced in experimental Wistar rats-HC1/ethanol-induced gastric lesions and Pylorus ligation-induced gastric lesions-were employed. In both models, the antiulcer activity of LA was compared with that of cim...

Purpose: Aloe buettneri A. Berger is commonly used in Togolese folk medicine to treat inflammation and gastric ulcer. In this study we investigated the anti-oedema, analgesic, antipyretic and ulcer healing properties of the hydro-alcohol extract of their leaves. Methods: Rat oedema paw were induced by the injection of 0.1 ml of formaldehyde 1%, tail flick method is used to study analgesic prope...

Endoscopic hemostasis is a useful treatment modality for gastric ulcer bleeding. However, it is sometimes difficult to achieve hemostasis in cases with arterial bleeding, especially those complicated with vascular abnormalities. We describe a case with gastric ulcer bleeding from a variant left gastric artery accompanied by congenital absence of the splenic artery. A 50-year-old female was admi...

Zuojin Pill (ZJP), a traditional Chinese medicine formula, consists of Coptis chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. in a ratio of 6:1 (w/w) and was first recorded in "Danxi's experiential therapy" for treating gastrointestinal disorders in the 15th century. However, the poor solubility of alkaloids from ZJP restricted the protective effect in treating gastritis and gastric ulce...

BACKGROUND The presence of gastric metaplasia allows helicobacter pylori to colonise the duodenum and this condition is thought to be acquired as a response to acid hypersecretion. This functional disorder, however, is present only in a subgroup of duodenal ulcer patients and, in addition, surface gastric metaplasia has been frequently found in the proximal duodenum of normal subjects and patie...

Gastric ulcer is a multifaceted, pluricausal illness. Knowledge of the pathophysiology of gastric ulcer disease remains incomplete. Current pharmacological management of gastric ulceration is directed primarily at the reduction or neutralization of gastric acid secretion despite evidence that patients with this disease often exhibit normal gastric secretory activity. Attempts have been made to ...

This research aimed to determine the potential protective effects ofPhaleria macrocarpafruit extracton rat gastric mucosal injury induced by ethanol andto clarify the roles of prostaglandinE2 (PGE2), transforming growth factor1 (TGF) and tumor necrosis factorTNF). Main methods: Seven groups of rats were orally pretreated with Tween20 as vehicle control group; Tween20 as ulcer group; 20 mg/kg of...

BACKGROUND: Gastric ulcer is one of the most common diseases in racehorses. Colic, weight loss and poor performance are some of the clinical signs. The second and third larval stages of the bot fly Gasterophilus spp live in the stomach of the horse. This parasite is often found in large numbers of horses in all of the countries. OBJECTIVES: The a...

The effect of alcoholic extract of Nigella sativa was investigated in rats to evaluate the anti-ulcer activity by using two models, i.e. pyloric ligation and aspirininduced gastric ulcer. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicate that the alcoholic extract significantly (P < 0.001) decre...