Background and Aim: Recurrent aphthous stomatitis (RAS) is the most common oral mucosal lesion in the general population. Different treatments have been used for RAS, including herbal medicine. In this study, the randomized clinical trials (RCTs) on the effect of medicinal plants on RAS were systematically searched and reviewed. Materials and Methods: The literature from 1985 to 2015 in the ...

background and aims: recurrent aphthous stomatitis (ras) is one of the most common ulcerative diseases of the oral mucosa. definitive etiology of ras has not been conclusively established. there is no certain treatment for aphthous but some drugs such as steroid are commonly used for treatment of ras. regarding the effect of zinc on healing process of epithelial layer and cell division, in this...

In Saccharomyces cerevisiae the ras-related protein Rholp is essentially the only target for ADPribosylation by exoenzyme C3 of Clostridium botulinum. Using C3 to detect Rholp in subcellular fractions, Rholp was found primarily in the 10,000 g pellet (P2) containing large organelles ; small amounts also were detected in the 100,000 g pellet (P3), and cytosol . When P2 organelles were separated ...

Dam overtopping failure and the resulting floods are hazardous events that highly impact inundated areas less predictable. The simulation of dam breach flood wave propagation is necessary for assessing hazards to provide precautions. In present study, a two-dimensional HEC-RAS model was used simulate from hypothetical Al-Udhaim on River, Iraq, dam-break along 100 km downstream site scenario. ma...

19 20 While there have been tremendous efforts to target oncogenic RAS signaling 21 from inside the cell, little effort has focused on the cell-surface. Here, we used 22 quantitative surface proteomics to reveal a signature of proteins that are 23 upregulated on cells transformed with KRASG12V, and driven by MAPK pathway 24 signaling. We next generated a toolkit of recombinant antibodies to sev...

abstract :  reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  the efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  cells expressing activated ras and t...

Abstract Summary: Guanine nucleotide exchange factors (GEF) control the rate-limiting step of physiologic RAS activation. In this issue Cancer Discovery, Hofmann and colleagues describe discovery a selective inhibitor targeting GEF, SOS1, along with its preclinical effects in suppressing KRAS-mutant tumor growth. See related article by et al., p. 142.

5. Howe JR, Klimstra DS, Maccia RD et al. Factors predictive of survival in ampullaty carcinoma. Ann Surg 1998; 228: 87-94. 6. Talamini MA, Moesinger RC, Pitt HA et al. Adenocarcinoma of the ampulla of Vater. A 28-year experience. Ann Surg 1997; 225: 590-599. 7. AIlema JH, Reinders ME, van Gulik TM at al. Results of pancreaticoduodenectomy for ampullaty carcinoma and analysis ofprognostic facto...