Background Thrombolytic therapy reduces mortality after acute myocardial infarction, even when treatment is initiated relatively late after onset of symptoms. The mechanism underlying this survival benefit is incompletely understood. Methods and Results In a prospectively designed ancillary study of a randomized, placebo-controlled trial of late thrombolytic therapy (LATE), the signal-averaged ...

Author Contributions: Dr Grey had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Role of the Sponsor: The Health Research Council of New Zealand had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manusc...

DEPRESSION IS A LEADING cause of disability in both developed and developing regions of the world, including Africa. In 2000, we conducted a community-based survey in an impoverished part of southwest Uganda that has been severely affected by the human immunodeficiency virus (HIV) epidemic. Using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) major depression cri...

Correction Contact me if this article is corrected. http://jama.ama-assn.org/cgi/content/full/jama;301/8/830 Correction is appended to this PDF and also available at Citations Contact me when this article is cited. This article has been cited 1 time. Topic collections Contact me when new articles are published in these topic areas. Randomized Controlled Trial; Drug Therapy; Drug Therapy, Other ...

OSTEOPOROSIS IS A MAJOR cause of disability and excess mortality in older women. Estrogen therapy has been used for treatment and prevention of osteoporosis; however, many older women are reluctant to use it because of adverse effects. Recent data from the Women’s Health Initiative demonstrated that postmenopausal women who took hormone therapy for approximately 7 years had decreased hip fractu...

In this paper, we develop and implement a methodology for drawing inference about subgroup effects in a two-arm randomized trial when subgroup status is only known for a non-random sample in each of the trial arms. The methodology is developed in the context of the MADIT II study, a randomized trial designed to evaluate the effectiveness of implantable defibrillators on survival.

1. THE NEED FOR A TRIAL 1.1 What is the problem to be addressed? The proposed randomized controlled two-centre pilot trial will assess the feasibility, tolerability and effect size of a program of exercise training to treat the post-thrombotic syndrome (PTS). Results of this pilot trial will be used to plan a larger, adequately powered, multicenter randomized trial of exercise training to treat...

Comparing the Effect of Different Doses Vitamin D Supplementation During Pregnancy on Prevention Adverse Outcomes; a Randomized Clinical Trial

Impact of intravenous dexmedetomidine on postoperative bowel movement recovery after laparoscopic nephrectomy: A consort-prospective, randomized, controlled trial

The Functional Correction of Forward Shoulder Posture with Kinesiotape Improves Chest Mobility and Inspiratory Muscle Strength: A Randomized Controlled Trial