objectives: saffron is the stigma of crocus sativus l., which has the potentials to play a role in the treatment of many diseases. although many researches are now going on this precious spice, there are few data on saffron safety in human, especially in patients with chronic mental illnesses. this study aimed to evaluate the short-term safety and tolerability of both saffron and crocin (its ma...

objective: long-term retention of pit and fissure sealants is crucial for their success. this clinical study evaluated the retention rate of a flowable composite resin (filtek supreme xt flowable restorative) compared to a conventional resin-based sealant (concise light cure white sealant) over 12 months. materials and methods: forty subjects aged 6 to 9 years were included in the study. using ...

in recent years, notable measures have been taken to protect the rights of participants in biomedical research in iran. the present study examines possible trends in adherence to ethical codes regarding informed consent after the development of the national code of ethics in biomedical research (ncebr) and establishment of research ethics committees. in this retrospective study, 126 dissertatio...

introduction: acute mania is a psychiatric emergency state that often requires rapid management. there are many different therapeutic protocols for this emergent situation. one of them is combination of moodstabilizers and antipsychotics. olanzapine which is now available in our country can be used for this purpose. methods and materials: in this study, we compared the effectiveness, rapidity o...

objective(s): crocin is the chemical ingredient primarily responsible for the color of saffron. it has different pharmacological effects such as antioxidant, anticancer and memory improving activities. crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. materials and methods: the study was a randomized, double-blind, placebo-controlled design consis...

EACH YEAR, MORE THAN 730 000 Americans experience a new or recurrent stroke, with resulting direct and indirect health care costs totaling $35 billion and $21.8 billion, respectively. Up to 85% of the approximately 566 000 stroke survivors experience hemiparesis, resulting in impairment of an upper extremity immediately after stroke, and between 55% and 75% of survivors continue to experience u...

objective: exposure to traumatic stressors lead to activation of arousal responses mediated by serotonergic and noradrenergic systems and it may cause a change in numerous neurotransmitters and neuroendocrine systems. there is ample experimental and clinical evidence to suggest that ginkgo biloba extract is neuroprotective and has antioxidant properties and can restore stress-induced elevation ...

background: the role and proper dose of pralidoxime in the treatment of organophosphorus (op) compounds poisoning is an unresolved issue .this study was designed to compare the regimen recommended by the world health organization (who) with the commonly used standard regimen of pralidoxime. methods: this was a randomized open labeled prospective study on op poisoned patients admitted to jss hos...

gliobalstoma multiforme (gbm) or grade 4 astrocytoma is the most malignant form of primary brain tumor. treatment of glioblastoma is difficult despite of surgery, radiotherapy and chemotherapy. patients with glioblastoma survive for less than 12 months. considering to biology function of glioblastoma, researchers have recently offered new therapeutic approaches such as cannabinoid therapy for g...

Comparison of the Therapeutic Effects Melatonin, Metformin and Vitamin E on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial