OBJECTIVE To quantify the effectiveness and safety of corticosteroids in the treatment of acute traumatic brain injury. DESIGN Systematic review of randomised controlled trials of corticosteroids in acute traumatic brain injury. Summary odds ratios were estimated as an inverse variance weighted average of the odds ratios for each study. SETTING Randomised trials available by March 1996. S...

Editor—The Save European Science campaign (www.SaveEuropeanResearch.org) was launched on 9 December 2003 out of concern for the future of academic and investigator led research in Europe with the advent of the European Union clinical trials directive (see p 240). It was launched from a cancer platform but is inclusive in spirit and has already gained momentum in cardiology, dermatology, and psy...

OBJECTIVES To present the updated results of systematic review of the current evidence for the effectiveness of hip protectors from reports of completed randomised trials, and to explore the evolution of that evidence. DESIGN Systematic review with meta-analysis. DATA SOURCES Cochrane Bone, Joint, and Muscle Trauma Group trials register (January 2005), Cochrane central register of controlle...

Abstract Aim There are presently no established standards on whether antibiotic prophylaxis is necessary during Kirschner wire (K-wire) fixation in order to reduce infection rates. The outcomes of vs K-wire fixation, were compared. Method A systematic review and meta-analysis carried out accordance with the Preferred Reporting Items for Systematic Reviews Meta-analyses (PRISMA) Guidelines, an e...