The reduction of glutathione by a heat-labile system in liver was discovered by Hopkins and Elliott (1). Later Mann (2) obtained a soluble enzyme preparation from liver which required, for the reduction process, a cofactor and glucose as hydrogen donor. Meldrum and Tarr (3) found that oxidized glutathione was reduced by rat blood and by yeast and demonstrated the function of TPNl as a cofactor ...

Neurons have been classified by their firing properties and by their differing dendritic characteristics, architectures, and biophysical properties, suggesting the existence of design principles and computational goals. From a classical viewpoint, dendrites provide the pathways that funnel the many subthreshold postsynaptic potentials (PSPs) toward the soma, where the propagated–summated result...

OPPELT, W. W., I. MACINTYRE, AND D. P. RALL. Magnesium exchange between blood and cerebrospinal @id. Am. J. Physiol. 205(s) : 959-962. 1 g63.-Magnesium exchange between plasma and cerebrospinal fluid (CSF) was studied in dogs using Mg2*C12 and MgClz. Normal CSF/plasma magnesium ratio in this animal is I .34. In face of a plasma magnesium concentration 300-400~~ of normal, the CSF magnesium only...

AIM To investigate the association between self-reported physical fitness level obtained by a single-item question and objectively measured fitness level in 30- to 49-year-old men and women. METHODS From the Danish 'Check Your Health Preventive Program' 2013-2014 fitness level was assessed in 2316 participants using the Aastrand test. Additionally, participants rated their physical fitness as...

It has been shown that adrenocorticotropic hormone will increase the phosphorylase activity of beef adrenal cortical slices in vitro (1). On the basis of this and other observations the hypothesis was proposed that the ACTHl effect on corticoid biosynthesis is mediated by the increased levels of TPNH which result from dehydrogenation of glucose 6-phosphate arising at an accelerated rate from gl...

Many reports state a marked reduction of catecholamine (CA) in cardiac tissue and an increased CA concentration of serum and urine in patients with congestive heart failure 1)-5). Thus, it is assumed that the function of the impared heart might be supported by the increased blood CA. It has been reported that the inotropic 6)-12) and chronotropic response 13)-16) of CA to the cardiovascular sys...

Let γ(G) denote the domination number of a graph G and let G H denote the Cartesian product of graphs G and H. We prove that γ(G)γ(H) ≤ 2γ(G H) for all simple graphs G and H. 2000 Mathematics Subject Classifications: Primary 05C69, Secondary 05C35 We use V (G), E(G), γ(G), respectively, to denote the vertex set, edge set and domination number of the (simple) graph G. For a pair of graphs G and ...

In assessing the potential health hazard a given mutagen might present to man, a number of extrapolations must be made from the test systems which are currently available. For the L5178Y mouse lymphoma cell assay system that we use, these extrapolations include: somatic versus germinal cells; single cells versus whole animals; transformed versus "normal" cells; and mouse versus human cells. All...

Expression of the HIV-1 envelope protein gp120 in brains of transgenic (tg) mice induces extensive neurodegeneration (Toggas, S. M., E. Masliah, E. M. Rockenstein, G. F. Rall, C. R. Abraham, and L. Mucke. 1994. Nature [Lond.]. 367:188-193.). To further analyze the pathogenesis of gp120-induced neurotoxicity and to assess the neuroprotective potential of human amyloid precursor proteins (hAPPs) ...

A stochastic model equation for nerve membrane depolarization is derived which incorporates properties of synaptic transmission with a Rall-Eccles circuit for a trigger zone. If input processes are Poisson the depolarization is a Markov process for which equations for the moments of the interspike interval can be written down. An analytic result for the mean interval is obtained in a special ca...