Objective. Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of Graves' disease (GD). The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP. Methods. Sixteen patients with GD/TPP were followed over a 14-year period. ATD was generally prescribed upfront for 12-18 months before RAI or surgery ...

Radioactive-iodine (RAI) therapy is typically unprevailing as anaplastic thyroid cancer (ATC) management, owing to the decrease in the endogenous sodium iodide symporter (NIS) expression. Therefore, new strategies for NIS re-induction are required to improve the efficacy of RAI therapy in ATC. In this study, we developed a novel high-throughput NIS enhancer screening platform using a dual repor...

The rationale and objectives for radioactive iodine (RAI) ablation remain perplexing to many. This review addresses the meaning, clinical context and the goals of "ablation": the RAI treatment after a total thyroidectomy. This article also aims to clarify the definition of a total thyroidectomy and how a thyroid remnant can introduce a confounding factor in the postoperative management of patie...

This is a case of follicular thyroid carcinoma with extensive lung, bone and brain metastases. Multi-modality treatments including total thyroidectomy, modified radical neck dissection, cranial radiotherapy and Iodine-131 (RAI) therapy were instituted. Post RAI therapy planar whole body scan showed RAI avid metastases in the skull, cervical spine, bilateral lungs and abdomen. With the use of SP...

Dr. P. D. Bose, M.B.; Lt.-Col. R. Bird* C.I.E., M.D., F.R.C.S., M.V.O., M.S., I.M.S.; Lt.-Col. R. P. Wilson, F.R.C.S., D.P.H., I.M.S.; Major N. P. Sinha, I.M.S.; Dr. Bepin Behari Ghose, M.B.; The Hon'ble Dr. Nil Ratan Sircar, M.A., M.D.; Dr. S. P. Sarbadliikary, c.l.E., M.b. ; Rai Satis Chandra Banerjee Bahadur, L M.S.; Rai U. N. Bralimaehari Bahadur, M.A., M.D., Ph.D.; Rai Haridhan Dutt Bahadu...

This study examines space–time characteristics of seasonal rainfall predictability in a tropical region by analyzing observed data and model simulations over Senegal. Predictability is analyzed in terms of the spatial coherence of observed interannual variability at the station scale, and within-ensemble coherence of general circulation model (GCM) simulations with observed sea surface temperat...

AIMS We compared the effects of total thyroidectomy (TTx) and radioiodine (RAI) administration on the course of thyroid hormones and thyroid-stimulating immunoglobulins (TSI) in patients with Graves' disease. METHODS We retrospectively studied 80 patients initially treated with antithyroid drugs and requiring either RAI (8.3 ± 1.7 mCi of (131)I; n = 40) or TTx (n = 40) as second-line therapy....