For several real-time applications it is critical that the failure of a network component does not lead to unexpected termination or long disruption of service. In this paper, we propose a scheme called RAFT (Resource Aggregation for Fault Tolerance) that guarantees recovery in a timely and resource-eecient manner. RAFT is presented in the framework of the Reliable Backbone (RBone), a virtual n...

Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche in a noncycling state and enter the cell cycle at long intervals. However, little is known about inter- and intracellular signaling mechanisms underlying this unique property of HSCs. Here, we show that lipid raft clustering is a key event in the regulation of HSC dormancy. Freshly isolated HSCs from the BM niche lack lipid ra...

Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications. We isolated lipid rafts of the protozoan parasite Trypanosoma brucei and determined the protein composition of lipid rafts in the cell. This analysis revealed a striking enrichment of flagellar proteins and ...

Providing the ability to any law enforcement officer to remotely transfer an image from any suspect computer directly to a forensic laboratory for analysis, can only help to greatly reduce the time wasted by forensic investigators in conducting on-site collection of computer equipment. RAFT (Remote Acquisition Forensic Tool) is a system designed to facilitate forensic investigators by remotely ...

Values of site factors in numerical simulation can have profound effects on the calculation accuracy. In order to fully understand the performance of rigid-pile composite foundation in tall buildings, this article set up an overall FEA model of a 25-storey frame-tube structure by considering the interaction of superstructure, foundation and ground. Thereafter, a detailed parametric study was pe...

CD45 is dynamically repositioned within lipid rafts and the immune synapse during T cell activation, although the molecular consequences of CD45 repositioning remain unclear. In this study we examine the role of CD45 membrane compartmentalization in regulating murine T cell activation. We find that raft-localized CD45 antagonizes IL-2 production by opposing processive TCR signals, whereas raft-...

The neural cell adhesion molecule (NCAM) has been reported to stimulate neuritogenesis either via nonreceptor tyrosine kinases or fibroblast growth factor (FGF) receptor. Here we show that lipid raft association of NCAM is crucial for activation of the nonreceptor tyrosine kinase pathway and induction of neurite outgrowth. Transfection of hippocampal neurons of NCAM-deficient mice revealed that...

Poli(4-vinilbenzil-g-stiren) [poli(VB-g-S)] aşı kopolimeri tersinir katılmalı/ayrışmalı zincir transfer (RAFT) ve serbest radikal polimerizasyon (FRP) teknikleri kullanılarak sentez edildi. Bu amaç için, 4-vinilbenzil klorür monomeri FRP yöntemiyle poli(4-vinilbenzil klorür) [poli-4-VBC] polimeri sentezlendi. İkinci aşamada, poli-4-VBC ile potasyum etil ksantat reaksiyona sokularak makro-RAFT a...

Research to reliably predict the seismic response of nuclear power stations with a pile-raft foundation is needed meet high safety requirements stations. In this study, scaled superstructure 4×3 foundation, which constructed in Shanxi kaolin clay, modelled. Accordingly, characteristics for are analyzed using dynamic centrifuge tests. particular, multiple earthquake motions different magnitudes ...

BACKGROUND/AIMS Trafficking, brush border membrane (BBM) retention, and signal-specific regulation of the Na+/H+ exchanger NHE3 is regulated by the Na+/H+ Exchanger Regulatory Factor (NHERF) family of PDZ-adaptor proteins, which enable the formation of multiprotein complexes. It is unclear, however, what determines signal specificity of these NHERFs. Thus, we studied the association of NHE3, NH...