On March 15, 2005, the U.S. Food and Drug Administration approved temozolomide (Temodar capsules, Schering-Plough Research Institute) for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment. Five hundred seventy-three glioblastoma multiforme patients were randomized to receive either temozolomide + radiot...

BACKGROUND Outcome data in young women with ductal carcinoma in situ (DCIS) are rare. The benefits of boost radiotherapy in this group are also unknown. We aimed to assess the effect of boost radiotherapy in young patients with DCIS. METHODS We included 373 women from 18 institutions who met the following inclusion criteria: having tumour status Tis and nodal status (N)0, age 45 years or youn...

Imaging has been integral to radiotherapy for decades. However, it has been within the last 20 years that phrases such as ‘image guidance’ have become part of mainstream radiotherapy vocabulary, and the use of all available imaging modalities within radiotherapy more common. So what is meant by ‘image guidance in radiotherapy’? This was one of the questions that the National Radiotherapy Implem...

What is radiotherapy? Radiotherapy is the treatment of disease, primarily malignant tumours, using electromagnetic and particle radiations. Radiotherapy has been used for skin cancers for nearly a century and in fact skin cancers were the first cancers to be treated and controlled with radiotherapy. During this protracted period, techniques of administering radiotherapy have developed continuou...

BACKGROUND After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. We compared targeted intraoperative radiotherapy with the conventional policy of whole breast external beam radio...

Accuracy of the radiotherapy requires some routine quality control and dosimetry calculations, which would be done by radiotherapy physicists. Due to the increasing use of computers and simulation software in medical science, as well as trends indicating its continued growth, this study aims to develop a new smart-phone application to perform common radiotherapy-related calculations. Computatio...

background: because of the adverse effects of ionizing radiation on fetuses, prior to radiotherapy of pregnant patients, fetal dose should be estimated. fetal dose has been studied by several authors in different depths in phantoms with various abdomen thicknesses (at). in this study, the effect of maternal at and depth in fetal dosimetry was investigated, using peripheral dose (pd) distributio...

introduction superficial x-ray therapy is one of the most important treatment methods in radiotherapy especially in the treatment of superficial skin lesions (up to 300 kvp). quality of the x-ray beam that can be expressed by half-value layer (hvl), are important indices for this type of treatment effective energy of photon and homogeneity coefficient (hc). materials and methods the hc of the s...

the improvement in survival and local control measures in children with neoplasm in the head and neck region may lead to increased iatrogenic adverse effects of treatment. the aim of this study was to report a new case of the long-term effects of chemoradiotherapy on oral health and dental development in a patient treated for hodgkin's disease at an early age. in this case report, a 26-year-old...

squamous cell carcinoma (scc) is the most common malignancy of the oral cavity. this study aims to evaluate different treatment procedures including neo-adjuvant, concurrent and adjuvant therapy in treating squamous cell carcinoma of the head and neck by a meta-analysis.the authors searched all electronic databases (medline, embase and cochrane) for all the articles published from 1970 to janua...