BACKGROUND Breast cancer (BC) is the most frequent cancer in European women with nearly 30% of the patients eventually developing metastases. Neuroendocrine differentiation is a rare event, but overexpression of somatostatin receptors in BC has been reported in many studies. CASE REPORT A patient with liver metastases from BC was treated with peptide receptor radionuclide therapy (PRRT). Comp...

Introduction: We describe a nephron-based dosimetry model for renal toxicity for radiopharmaceutical therapy suited to the nonuniform activity distribution of radiopharmaceutical. In radiopharmaceutical therapy, renal toxicity is observed while whole-kidney and renal cortex absorbed dose values are below toxicity thresholds established by external beam and targeted radiope ptid...

Purpose. The purpose of the current study was search for evaluation criterion radiosensitivity bone metastases various origins. Materials and methods. first part presents a modern classification pain, method its evaluation, mechanisms features metastatic pain. radiobiological patterns pain relief in low-dose anti-inflammatory radiation therapy were also considered. analysis these testifies favo...

Skeletal metastases or secondary cancerous lesions in bone, are common in patients suffering from breast, lung and prostate cancer, in the advanced stage of the disease. These metastatic lesions in skeleton, often lead to excruciating pain and other related symptoms such as: lack of mobility, neurological deficits, depression, anxiety, anger, fear of death etc., which adversely affect the quali...

The internal dosimetry schema of the Medical Internal Radiation Dose (MIRD) Committee of the Society of Nuclear Medicine has provided a broad framework for assessment of the absorbed dose to whole organs, tissue subregions, voxelized tissue structures, and individual cellular compartments for use in both diagnostic and therapeutic nuclear medicine. The schema was originally published in 1968, r...

Bone-seeking radiopharmaceuticals (RF) are an effective systemic pain-palliative treatment schedule in patients with disseminated bone disease. This treatment relies on selective uptake and prolonged retention of RF at sites of increased osteoblastic activity, while the potential toxicity of systemic administration is reduced by relatively selective tumour targeting. The main theoretic advantag...

Background: The purpose of this study was to find the accurate absorbed dose in the femur bone marrow during the X-ray radiography for constant mAs and AEC techniques. Materials and Methods: The DOSXYZnrc was used to simulate radiation doses in two human femurs during diagnostic radiography. EGSnrc phantoms produced from actual CT images of human femurs were modified by adding seven micrometre ...

Background: The present study aimed to investigate the equivalent dose in vital organs, including heart and lung, due to secondary particles produced during breast proton therapy. Materials and Methods: The numerical ORNL female-phantom was improved and simulated using the Monte Carlo MCNPX code. The depth-dose profile of proton beams with different energies was simulated. The proper energy ran...

Introduction: Radiation lobectomy (RL) is defined as the transarterial administration of high-dose radioactive microspheres to liver malignancies with intent inducing ipsilateral tumor ablation and contralateral hypertrophy. The biological characteristics therapy surviving cells their microenvironment remain unstudied. Methods: Fourteen patients received RL, which colorectal metastasis group (n...

Members of the epidermal growth factor receptor, EGFR, family are interesting as targets for radionuclide therapy using targeting agents labeled with α- or β-emitting radionuclides, especially when EGFR-positive colorectal carcinomas, CRC, are resistant to EGFR inhibiting agents like cetuximab and various tyrosine kinase inhibitors. The expression of EGFR, HER2 and HER3 was therefore analyzed i...