Radioactive decay of naturally occurring nuclides provides the basis for the nearly all quantitative temporal constraints on geophysical phenomena, from climate dynamics on scales of 10-10 yr, to planetary differentiation over 10-10 yr. In general there are few geologic problems that are not accessible by radioisotopic chronometers, partly because of the wide range of radioactive parent nuclide...

Radioisotopic angiocardiography has been performed in 120 patients after the intravenous injection of 99mTc pertechnetate. A scintillation camera and a variable timelapse videoscintiscope were used. The results indicate that the method permits identification and physiologic assessment of a wide variety of congenital and acquired cardiovascular lesions, including septal defects, valvular stenosi...

The most widely cited procedures for radiolabeling antibodies with zirconium-89 for immuno-PET require multi-milligram amounts of antibody which can be cost-prohibitive, particularly during the research and development process. We therefore sought to develop a reliable (89)Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale.

Microvascular erythrocyte sequestration, the characteristic pathological feature of falciparum malaria, was evaluated using a mathematical model in 46 patients with severe infections. From admission radioisotopic circulating red cell volumes and simultaneous venous hematocrits, the model-derived sequestrum hematocrit (mean [95% confidence limits]: 0.70 [0.43-0.97], n = 29) was twice that of per...

The nucleotide excision repair pathway removes ultraviolet (UV) photoproducts from the human genome in the form of short oligonucleotides ∼ 30 nt in length. Because there are limitations to many of the currently available methods for investigating UV photoproduct repair in vivo, we developed a convenient non-radioisotopic method to directly detect DNA excision repair events in human cells. The ...

A model for the emplacement, bioturbation, and preservation of fine scaled sedimentary strata has been used to evaluate the impact of interacting physical and biological sedimentary processes on preserved sedimentary fabric in three contrasting shelf and estuarine depositional settings: Eckernförde Bay, German Baltic Sea; the Eel Shelf, northern California, USA; and the northern Gulf of Alaska ...

Analysis of acquired nuclear detector gamma-ray signals for recognition of present radioisotopic signatures is crucial to national security and security applications. Identification algorithms must be accurate and rapid. Artificial intelligence is a scientific field with a variety of tools suitable to implement automated processing of nuclear signals. The use of low resolution portable detector...