PURPOSE To investigate the possible protective effects of aminoguanidine (AG ) on lung damage in whole body irradiated rats. METHODS To evaluate the biological damage of radiation on rat lung tissue, lipid peroxidation products were measured using biochemical parameters. Thirty Wistar albino rats were divided into three subgroups: control (C) , irradiation alone (RT), and RT + AG combined. Af...

The effectiveness of ulinastatin and methylprednisolone in treating pathological changes in mice with radiation-induced lung injury (RILI) was evaluated. Forty C57BL/6 female mice received whole-chest radiation (1.5 Gy/min for 12 min) and were randomly allocated into Group R (single radiation, n = 10), Group U (ulinastatin treatment, n = 10), Group M (methylprednisolone treatment, n = 10), or G...

PURPOSE New treatment strategies aimed at damaging tumor vasculature could potentially improve tumor response to radiation therapy. We recently showed that anionic phospholipids, principally phosphatidylserine, are specifically exposed on the luminal surface of tumor blood vessels. Here we tested the hypothesis that radiation therapy can increase phosphatidylserine exposure on lung tumor vascul...

As compared to conventional photon radiation heavy ions may offer specific therapeutic advantages in radiation oncology with respect to the higher relative biological effectiveness (RBE) at beam terminus. It has been demonstrated for heavy ion irradiation that the RBE in irradiated normal tissue, especially for acute effects is only slightly increased. However, since normal tissue reactivity, i...

Although radiation therapy is commonly used for treatment for many human diseases including cancer, ionizing radiation produces reactive oxygen species that can damage both cancer and healthy cells. Synthetic triterpenoids, including CDDO-Me, act as anti-inflammatory and antioxidant modulators primarily by inducing the transcription factor Nrf2 to activate downstream genes containing antioxidan...

Concentration of hyaluronic acid (HA) in the lungs increases idiopathic pulmonary fibrosis (IPF). HA is involved organization fibrin, fibronectin, and collagen. has been proposed to be a biomarker potential target for antifibrotic therapy. Hyaluronidase (HD) breaks down into fragments, but subject rapid hydrolysis. A conjugate poloxamer hyaluronidase (pHD) was prepared using protein immobilizat...

An unqualified answer to the above question is "yes". A qualified response, however, requires that the word, "nonirradiated", be defined. A truly nonirradiated lung represents the pulmonary parenchyma that is not exposed to any type or amount of radiation. Currently, there is sufficient scientific basis to consider that this nonirradiated normal lung parenchyma can suffer injury caused by radia...

Thoracic radiotherapy causes damage of normal lung tissue, which limits the cumulative radiation dose and, hence, confines the anticancer efficacy of radiotherapy and impacts the quality of life of tumor patients. Ras-homologous (Rho) small GTPases regulate multiple stress responses and cell death. Therefore, we investigated whether pharmacological targeting of Rho signaling by the HMG-CoA-redu...