OBJECTIVE To determine the potential immediate applicability of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and TRAIL-R2, the apoptotic forms of TRAIL-Rs, for preclinical testing. DESIGN AND SETTING Head and neck squamous cell carcinoma (HNSCC) tumors were studied for TRAIL-R1 and TRAIL-R2 expression by immunohistochemical analysis. In addition, matched tumor...

OBJECTIVE Recent reports have suggested that the existence of associations between hormonal dysregulation and chronic upregulation of inflammatory markers, which may cause obesity-related disturbances. Thus, we examined whether acylated ghrelin (AcylG) and total ghrelin (TotG) levels could be associated with the following inflammatory markers: C-reactive protein (CRP), tumor necrosis factor alp...

Stimulating tumor cell senescence and apoptosis are proven methods for therapeutically combating cancer. However, senescence and apoptosis are conventionally viewed as parallel, not sequential, processes. We have discovered that the metastasis-promoting phosphatase, PRL-3, is transcriptionally regulated by the NF-ĸB pathway in triple-negative breast cancer (TNBC) cells, and that PRL-3 knockdown...

We describe the cloning and characterization of tumor necrosis factor receptor (TNF-R)-associated ubiquitous scaffolding and signaling protein (TRUSS), a novel TNF-R1-interacting protein of 90.7 kDa. TRUSS mRNA was ubiquitously expressed in mouse tissues but was enriched in heart, liver, and testis. Co-immunoprecipitation experiments showed that TRUSS was constitutively associated with unligate...

The molecular regulation of the recruitment of initial signaling complexes at the TNF-R1 is poorly defined. We demonstrate here that within minutes internalized TNF-R1 (TNF receptosomes) recruits TRADD, FADD, and caspase-8 to establish the "death-inducing signaling complex" (DISC). In addition, we identified the TNF-R1 internalization domain (TRID) required for receptor endocytosis and provide ...

INTRODUCTION Sorafenib, a multitarget kinase inhibitor, targets members of the mitogen-activated protein kinase (MAPK) pathway and VEGFR kinases. Here we assessed the association between expression of sorafenib targets and biomarkers of taxane sensitivity and response to therapy in pre-treatment tumors from patients enrolled in ECOG 2603, a phase III comparing sorafenib, carboplatin and paclita...

In a previous work [1] matter models such that the energy density ρ ≥ 0, and the radialand tangential pressures p ≥ 0 and q, satisfy p + q ≤ Ωρ, Ω ≥ 1, were considered in the context of Buchdahl’s inequality. It was proved that static shell solutions of the spherically symmetric Einstein equations obey a Buchdahl type inequality whenever the support of the shell, [R0, R1], R0 > 0, satisfies R1/...

The purpose of this study was to assess and compare the prevalence meniscal, ligament cartilage lesions on knee MRI in a series age- sex-matched patients with without medial meniscal ossicle. Forty-two examinations obtained 42 (36 men, 6 women; mean age, 42.5 ± 22.2 [SD] years; range: 19–65 years) which ossicle present were compared 41.8 20.6 no ossicles present. Two radiologists (R1, R2) blind...

Four identical 37.5 Liter UASB reactors R1, R2, R3 and R4 were used to study the effect of sulfate concentration on granule formation. Diluted molasses with COD range 1000–1300 mg/l were used as feed and acclimated cow manure was used as seed. Concentration of sulfate ions in the four reactors were 100, 500, 1000 and 1500mg/l. Granules were observed in R2 after 33 days from startup time, while ...

CONTEXT The impact of R1 resection on outcomes in patients with pancreatic ductal adenocarcinoma (PDAC) is unclear, with most studies assessing survival for up to 5 years. OBJECTIVE The aim of this study was to evaluate the prognostic influence of R1 and R0 resection on >5-year survival in patients with PDAC. MATERIAL AND METHODS Of the 271 patients with PDAC who underwent pancreatic res...