A series of new quinazolione derivatives containing a conjugate sytem 13 a-l were synthesized via three step-procedure. The first step is the condensation 5-hydroxyanthranilic acid (10) at 160oC for 2 h to afford intermediate 11 in high yield. This was then reacted with n-butylamin acetic 14 give 12 92%. Finally, reaction different aldehydes 140oC 14h furnished conjugates 13a-l 62-81%. bioassay...

objective(s) quinazolinones are heterocyclic compounds, with biological and pharmacological activities, such as inhibiting some proteins, enzymes and reducing blood lipids. materials and methods following previous results of our group, effects of two new derivatives of quinazolinones 9(3)-quinazolinone-2-propyl-2-phenylethyl (qppe) and 9(3)-quinazolinone-2-ethyl-2-phenylethyl (qepe) on livers, ...

Quinazolinone compounds have been shown to have antitumor activity in many human cancer cell lines. In the present study, we investigated the anti-metastatic activity of MJ-33 (2-(3-ethoxyphenyl)-6-pyrrolidinylquinazolinone), a novel quinazolinone derivate, and the signaling pathway of MJ-33 in human prostate cells. MJ-33 exhibited a growth inhibitory effect on DU145, LNCaP and PC-3 cells by MT...

We are developing a noninvasive approach for targeting imaging and therapeutic radionuclides to prostate cancer. Our method, Enzyme-Mediated Cancer Imaging and Therapy (EMCIT), aims to use enzyme-dependent, site-specific, in vivo precipitation of a radioactive molecule within the extracellular space of solid tumors. Advanced methods for data mining of the literature, protein databases, and know...

quinazolinones are interesting materials because of their valuable biological effects. in this study some new 2,3-disubstituted-4(3h)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. in the last step, a single acylation on the hydrazine moiety afforded final compounds. the structures...