Assessment of myocardial viability 1>rior to revascularization procedures is an important clinical consideration for improved functional recovery of regional left ventricular dysfunction. In chronic coronary artery disease, impaired left ventricular function , at least in part, is due to ischemic or hibernating myocardium rather than just myocardial fibrosis. Functional recovery of the left ven...

BACKGROUND The purpose of this study was to investigate cardiac events in patients with transient left ventricle (LV) dilation on stress myocardial perfusion single-photon emission computed tomography images (MPI). METHODS AND RESULTS Consecutive patients (n=53, 31 males, mean age 71 years) with transient LV dilation on thallium-201 stress MPI (treadmill: 21, pharmacologic: 32) were followed ...

To evaluate the difference in myocardial damage between primary aldosteronism and untreated essential hypertension, we performed thallium-201 myocardial single-photon emission computed tomography in 10 patients with primary aldosteronism and 10 patients with essential hypertension who were matched for age, sex, blood pressure, and the severity of left ventricular hypertrophy for primary aldoste...

OBJECTIVE To investigate, by thallium-201 scanning, circulation in the muscles of the lower limb (LL) in diabetic patients without clinical peripheral vascular disease but with a high cardiovascular risk profile. RESEARCH DESIGN AND METHODS A total of 80 diabetic patients (76 patients with type 2 diabetes, mean age 57.3 years, duration of diabetes 13.0 +/- 7.5 years) with more than one additi...

Myocardial uptake and washout of thallium-201 (20TI) were studied in an experimental dog model in which regional blood flow to the posterior wall was varied by transient 2-minute occlusion of the circumflex coronary artery to produce transient ischemia and reactive hyperemia. Thallium-201 myocardial activity in a region of interest was determined continuously after i.v. administration by a gamm...

To evaluate the difference in myocardial damage between primary aldosteronism and untreated essential hypertension, we performed thallium-201 myocardial single-photon emission computed tomography in 10 patients with primary aldosteronism and 10 patients with essential hypertension who were matched for age, sex, blood pressure, and the severity of left ventricular hypertrophy for primary aldoste...

Digitalis has been shown to improve the impaired ventricular function associated with coronary artery disease as well as to increase myocardial oxygen consumption and produce coronary vasoconstriction. To elucidate the net result of these contrasting effects, six patients with coronary artery disease and left ventricular ejection fractions less than 0.50 had 1.0 mCi thallium-201 injected intrav...

Background: The incorporation of thallium-201 into 8-hydroxyquinoline was targeted for cell labeling due to interesting physical properties and wide availability of this nuclide as a single photon emission computed tomography (SPECT) radionuclide. Materials and Methods: Thallium-201 (T1/2=3.04 d) in Tl+ form was converted to Tl3+ cation in presence of O3/6M HCl and di-isopropyl ether, controlle...

Patients with hypertension may present with symptoms of angina with or without coronary artery disease (CAD). The pretest likelihood for coronary artery disease increases with concomitant diabetes mellitus, hypercholesteremia, and other risk factors. Standard noninvasive evaluation in patients with a high likelihood of CAD includes stress (exercise or persantine) electrocardiography and SPECT t...

OBJECTIVE To determine the best test(s) for predicting functional recovery of hibernating myocardium after reperfusion. METHODS A prospective study to compare echocardiographic left ventricular diastolic wall thickness (> or =5 mm), low-dose dobutamine echocardiography and rest-redistribution thallium-201 scintigraphy, alone and in combination, for predicting recovery of left ventricular akin...