The KNOTTIN website and database organize information about knottins or inhibitor cystine knots, small disulfide-rich proteins with a knotted topology. Thanks to their small size and high stability, knottins provide appealing scaffolds for protein engineering and drug design. Static pages present the main historical and recent results about knottin discoveries, sequences, structures, folding, f...

This appendix contains the proof of Theorem 2 which is the main result for the general version of the model presented in Section II of the paper. The numbering here (of equations, result, and definitions, etc.) follows the numbering in the published paper. Assumptions 6-10, which are stated in the paper, are assumed implicitly throughout. A single subscript will be used to denote the number of ...

XML data consists of a very flexible tree-structure which makes it difficult to support the storing and retrieving of XML data. The node numbering scheme is one of the most popular approaches to store XML in relational databases. Together with the node numbering storage scheme, structural joins can be used to efficiently process the hierarchical relationships in XML. However, in order to proces...

In this paper we describe the generalized method for the prediction of the LOS propagating characteristics in an urban Microcell using the ray tracing technique. The conventional ray tracing techniques suffer from finite number of rays and can’t ensure the exact solution. But the image methods allow us to treat the infinite number of rays and thus obtain the accurate solution. Also there is the...

A program to automate the finite element method (FEM) using various soft-computing techniques is presented. The overall program is discussed, and the implementations of three specific sub-problems (mesh placement, node numbering, and adaptive meshing) are described. It is also argued that the overall architecture of an “intelligent finite element package” can serve as a “test-bed” for many soft...

despite providing robustness, high-gain observers impose a peaking phenomenon, which may cause instability, on the system states. in this paper, an adaptive saturation is proposed to attenuate the undesirable mentioned phenomenon in high-gain observers. a real-valued and differentiable sigmoid function is considered as the saturating element whose parameters (height and slope) are adaptively tu...

Standard compact scheme or upwind compact scheme have high order accuracy and high resolution, but cannot capture the shock without oscillations. In this paper, modified compact scheme is developed by using an effective shock detector to block upwinding compact scheme to cross the shock, a control function, and an adaptive scheme which uses some WENO flux near the shock. The new scheme makes th...

Abstract I will comment on the comments by groups of three reviewers separately. First all, thank all providing a first round reports in order for me to get rid obvious mistakes. In second were free qualities my revised version. am not change paper when giving what would be honest quality final However, have go at rejoinders according symposium rules. keep section numbering authors make it easi...

We present a simple scheme for approximating a surface given a set of 3D points sampled on it via a retangular adaptive (RA) triangulation. This scheme considers an average on the neighboring triangles of a vertex to define an intermediate polinomial surface that better represents the surface.