Mongrel dogs (29) were anesthetized, paralyzed, and ventilated at a constant minute volume. AaD02 breathing air and 100% O2, venous admixture breathing air (Qva/Qt) and 100% O2 (Qs/Qt), single-breath diffusing capacity for CO (DLCO), and total pulmonary resistance (RL) and pulmonary compliance (CL) were measured before and after pulmonary embolization with autologus in vivo venous thrombi. Nine...

OBJECTIVE We explored the potential association between antipsychotics and QT/QTc duration changes in hospitalized male patients with psychotic disorders. METHODS The chart review was conducted on 184 male patients hospitalized between 2013 and 2015 at the Psychiatric Clinic of Pisa, Italy. Patients who were treated with one atypical antipsychotic at the time of the ECG recording were 109/184...

BACKGROUND Electrophysiological changes in cirrhosis are well known but least investigated especially in our country hence we wanted to see electrophysiological changes especially QT interval in cirrhotic patients. METHODS A cross-sectional study was conducted at Aga Khan University Hospital Karachi (AKUH) in which medical records (duration 2008-2010) of cirrhotic patients were reviewed. RE...

INTRODUCTION Hemodialysis (HD) has impact on the cardiovascular system by inducing changes in the characteristics of body fluids such as PH, temperature and electrolyte concentrations. In the previous studies, prolongation of the QT interval and increase of QT dispersion have been reported during HD sessions. These changes were more significant while using solutions with less potassium and high...

In a previous communication (1) we have briefly described the electrocardiographic changes of the QT interval during exercise in normal subjects. On the average the corrected QT interval or K was 7% greater than that observed during rest, and with the onset of recovery it diminished by 9%o within the first two minutes and gradually returned to the original value at rest. There was no significan...

electrocardiographic study of 50 healthy markhoz goats ranging from less than 1 to more than 3 years inage was carried out. the heart rate varied from 99 to 123 beats/min with a mean of 110 beats/min. there wasa significant difference between the heart rate of goats in 3 age groups (pt waves and qt interval in base apex lead, qrs wave in lead i, p-r and pq interval in avf lead were higherand du...

Before novel drugs are approved, the US FDA mandates an adequate safety evaluation, including evaluation of measurable QT interval changes. Defining the safety profile of drugs for patients in disease states is a particular challenge, including patients suffering ST-elevation myocardial infarction (STEMI). Although STEMI therapies are effective in restoring perfusion at the epicardial level, on...

BACKGROUND AND OBJECTIVES Degarelix is a gonadotropin-releasing hormone antagonist registered for the treatment of advanced hormone-dependent prostate cancer. Treatment causing androgen deprivation is associated with QT prolongation and this study investigated whether degarelix at supratherapeutic concentrations has an intrinsic effect per se on cardiac repolarisation and the QT interval. MET...

BACKGROUND Chronic arsenic exposure is associated with cardiovascular abnormalities. Prolongation of the QT (time between initial deflection of QRS complex to the end of T wave) interval and profound repolarization changes on electrocardiogram (ECG) have been reported in patients with acute promyelocytic leukemia treated with arsenic trioxide. This acquired form of long QT syndrome can result i...

Acute effects of sex steroid hormones likely contribute to the observation that post-pubescent males have shorter QT intervals than females. However, the specific role for hormones in modulating cardiac electrophysiological parameters and arrhythmia vulnerability is unclear. Here we use a computational modeling approach to incorporate experimentally measured effects of physiological concentrati...