Attempts have been made to clarify the effect of pyridoxine deficiency as well as its overdosis on growth of transplantable tumors in mouse and rat. The growth of transplantable solid tumor in pyridoxine deficient animals was remarkably suppressed while that of ascites tumor was not. The tumor bearing host was administered with a large amounts of pyridoxine and pyridoxal phosphate resulting in ...

Borax is one of the compounds boron (B), which widely used as an anti-fungal, wood preservative, and antiseptic in cosmetics. Boron can form complexes with biomolecules such pyridoxine, so it interesting to know interaction between borax pyridoxine. This study seeks investigate complexation boron, obtained from borax, pyridoxine under various conditions time, temperature, amount The resulting c...

MICROCYTIC hypochromic anemia induced by a diet deficient in pyridoxine is well documented in swine,’ monkeys,2 dogs,3 cats,4 ducks,5 and chicks.#{176}In man, pyridoxine deficiency anemia was first described in 1956 by Harris et al.;7 subsequently an increasing number of cases have been reported by others. In 1953, Synderman et al.8 produced pyridoxine deficiency in two infants with cerebral de...

The natural vitamin, pyridoxine, in the millimolar range is toxic to cultured rat hepatoma cells. A pyridoxine-resistant Fu5-5 rat hepatoma cell line was established by a stepwise increase in the concentration of pyridoxine in the medium. The newly established cell line, referred to as clone 10 (Cl.10), is resistant to killing by pyridoxine in concentrations up to 5 mM. Saturation kinetics for ...

The natural vitamin, pyridoxine, in the millimolar range is toxic to cultured rat hepatoma cells. A pyridoxine-resistant Fu5-5 rat hepatoma cell line was established by a stepwise increase in the concentration of pyridoxine in the medium. The newly established cell line, referred to as clone 10 (CI. 10), is resistant to killing by pyridoxine in concentrations up to 5 rrtM. Saturation kinetics f...

Growth of FRM cells was inhibited by the addition of pyridoxine in a dose-dependent manner. Use of 5 mM pyridoxine caused an almost complete arrest of cell growth. Pyridoxal was as effective as pyridoxine, but pyridoxamine showed weak inhibitory action. Electron-microscopic examination of control cells revealed large nuclei and cellular membranes with villi, but, in pyridoxine-treated cells, co...

Three levels of lysine (90, 100 and 110% of Ross requirement) and of pyridoxine (3, 6 and 9 mg kg-1) were used in a 3 × 3 factorial experiment to investigate the growth and blood antioxidant ability of broilers under high ambient temperature. None of the dietary supplements affected the weight gain during the starter and grower periods. Although no significant differences were detect...

Pyridoxine (vitamin B(6)) protects neurons against neurotoxicity. An excessive release of glutamate is widely considered to be one of the molecular mechanisms of neuronal damage in several neurological diseases. We investigated whether pyridoxine affected glutamate release in rat cerebral cortex nerve terminals (synaptosomes). Pyridoxine inhibited the release of glutamate that was evoked by exp...

Contribution of intrinsic neuronal factors in the generation of cortically driven seizures. electrographic seizures are generated intracortically. The cellular and ionic bases of cortically generated spontaneous seizures are not fully understood. Here, we investigated spontaneously occurring seizures consisting of spike-wave complexes intermingled with fast runs in ketamine-xylazine anesthetize...

Two observations stimulated the interest in vitamin B-6 and alkaline phosphatase in brain: the marked increase in plasma pyridoxal phosphate and the occurrence of pyridoxine responsive seizures in hypophosphatasia. The increase in plasma pyridoxal phosphate indicates the importance of tissue non-specific alkaline phosphatase (TNAP) in transferring vitamin B-6 into the tissues. Vitamin B-6 is in...