To find new anthelmintics against parasites living in host tissues, we used an in vitro assay to screen isoquinoline alkaloids for nematocidal activity on the larva of dog roundworm, Toxocara canis. To evaluate the efficacy of anthelmintics in vitro, Tsuda et al. previously introduced the concept of Relative Mobility (RM) of Toxocara larvae. After improvement of the assay system using image dat...

Introduction Gastrointestinal nematodes in grazing animals cause major production losses and represent an animal welfare problem worldwide. For decades use of anthelmintics has been central in the control programs of these parasites. This intensive use of anthelmintic drugs has resulted in problems with resistance to the anthelmintic drugs available today. Resistance to all classes of broadspec...

Environmental contamination and the egg excretion pattern of the ascarid Parascaris equorum (Nematoda) was investigated in relation to anthelmintic treatment on a Swedish stud farm. Faecal samples from 15 foals, dewormed every 8th-week with a paste formulation of ivermectin at the standard dose rate of 0.2 mg/kg bodyweight, were collected at five sampling occasions between August and November 2...

Modes of action of anthelmintic drugs are described. Some anthelmintic drugs act rapidly and selectively on neuromuscular transmission of nematodes. Levamisole, pyrantel and morantel are agonists at nicotinic acetylcholine receptors of nematode muscle and cause spastic paralysis. Dichlorvos and haloxon are organophosphorus cholinesterase antagonists. Piperazine is a GABA (gamma-amino-butyric ac...

INTESTINAL AND LUNGWORM PARASITE CONTROL Intestinal parasites affecting donkeys are similar to those that affect horses. These include nematodes (large and small strongyles, ascarids, pinworms), bots, and Cestodes (tapeworms). Basic principles of parasite control are the same as for larger equines. Medications used with success in donkeys include fenbendazole, ivermectin, albendazole, and pyran...

Recent worm epidemics proved beyond any doubt that the existing centralized worm containment mechanisms are no longer adequate to protect vulnerable systems, resulting in a shift towards distributed cooperative systems that aim to safeguard and immunize the susceptible population by automatically vaccinating them. We present PROMIS, a P2P based algorithm that provides its participants with earl...

Intestinal strongyles are the most problematic endoparasites of equids as a result of their wide distribution and the spread of resistant isolates throughout the world. While abundant literature can be found on the extent of anthelmintic resistance across continents, empirical knowledge about associated risk factors is missing. This study brought together results from anthelmintic efficacy test...

Ileal impaction is prevalent in the south-eastern USA, where feeding of Coastal Bermuda hay has been implicated as a risk f a c t o r. A l t e r n a t i v e l y, infection with the tapeworm Anoplocephala perfoliata has been identified as a risk factor f o r ileal impaction in the UK. We hypothesised that feeding Coastal Bermuda hay and failure to administer routinely an anthelmintic with effica...