The charge density distribution in deuterated cytosine monohydrate [4-(2H2)-amino-2(1H)-(1-2H)-pyrimidinone], C4H2D3N3O.D2O, Mr = 134.15, monoclinic, P2(1)/c, a = 7.714 (1), b = 9.825 (1), c = 7.506 (2) A, beta = 100.52 (1) degrees, Z = 4, has been determined from 1432 X-ray reflections [sin theta/lambda less than 1.15 A-1, Mo K alpha, lambda = 0.7093 (1) A] collected at 82 (2) K. Least-squares...

The novel biotransformation of an aminopyrrolidine to an aminopiperidine during the metabolism of 5-(4-chlorophenyl)-3-methyl-2-((2R)-2-(((1-methylethyl)amino)methyl)-1-pyrrolidinyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone (AMG657417) was investigated using the NADPH-fortified S9 fraction from human liver. The major metabolite (M18) had a protonated molecule (MH(+) m/z 438) identical to that of AMG6...

Supramolecular biomaterials based on ureido-pyrimidinone (UPy) moieties are versatile polymer materials as their function can be tailored to the application. These UPy-materials designed into coatings, self-healing polymers, hydrogels and elastomers. The biocompatibility of UPy-based degradation products is a long-term success requirement for many regenerative medicine biomedical applications. ...

Regeneration of lost myocardium is an important goal for future therapies because of the increasing occurrence of chronic ischemic heart failure and the limited access to donor hearts. An example of a treatment to recover the function of the heart consists of the local delivery of drugs and bioactives from a hydrogel. In this paper a method is introduced to formulate and inject a drug-loaded hy...

In this work, γ-Fe2O3@KSF as a stable heterogeneous and magnetic catalyst was prepared by the successive coating of γ-Fe2O3 shell on KSF core. The prepared reagent was characterized using different methods including FT-IR, XRD, TGA and SEM techniques and used for the one-pot synthesis of pyrano-pyrimidinone derivatives. All reactions were performed under mild conditions, during short reaction t...