Both the behavioural and the morphological analyses confirm the special role of the dewclaw in the cheetah: a strong hook to stop running animals by using the energy of the victim itself. However, this would hardly be an explanation for the rather large dewclaw in the puma. The present finding of the puma as an intermediate between the cheetah and other large felids for dewclaw size, supports t...

Rapid prototyping (RP) of microfluidic channels in liquid photopolymers using standard lithography (SL) involves multiple deposition steps and curing by ultraviolet (UV) light for the construction of a microstructure layer. In this work, the conflicting effect of oxygen diffusion and UV curing of liquid polyurethane methacrylate (PUMA) is investigated in microfabrication and utilized to reduce ...

Hsp90 is widely overexpressed in cancer cells and believed to be essential for the maintenance of malignant phenotypes. Targeting Hsp90 by small molecules has shown promise in solid and hematologic malignancies, which likely involves degradation of client oncoproteins in a cell-type–specific manner. In this study, we found that structurally unrelated Hsp90 inhibitors induce DNA damage and apopt...

Background Glioblastoma is one of the most aggressive and common malignancies of the central nervous system in humans. Owing to the correlation of high Hsp90 expression with prognosis and clinical pathology features of diverse types of cancer, targeting Hsp90 with small-molecule inhibitors has become a promising anticancer strategy. Purpose In this study, we aimed to explore the possibility o...

Abstract Pumas ( Puma concolor ) were eliminated from most of the eastern USA a century ago. In past couple decades, their recovery in West has increased puma dispersal into Midwest, with some individuals even traveling to East Coast. We combined published expert opinion data and habitat suitability index an analysis that identified 17 areas Upper Ozarks, Appalachia, New England could potential...

Capturing small carnivores is often necessary for obtaining key ecological data. We compared the efficiency of box and leg-hold traps, using live and dead bait, to capture six carnivore species (Herpailurus yagouaroundi (E. Geoffroyi, 1803), Leopardus tigrinus (Schreber, 1775), Nasua nasua (Linnaeus, 1766), Cerdocyon thous (Linnaeus, 1766), Eira barbara (Linnaeus, 1758), and Galictis cuja (Moli...

We read with great interest the paper of Puma et al. [1], in which they propose an external longitudinal titanium support after sternochondroplasty for severe asymmetric pectus excavatum repair. Pectus excavatum has probably been the chest deformity with the largest number of proposed techniques for its correction over the years. The very interesting solution proposed by Dr Puma gives rise to a...