Adult brain function and behavior are influenced by neuronal network formation during development. Genetic susceptibility factors for adult psychiatric illnesses, such as Neuregulin-1 and Disrupted-in-Schizophrenia-1 (DISC1), influence adult high brain functions, including cognition and information processing. These factors have roles during neurodevelopment and are likely to cooperate, forming...

S erious and chronic childhood psychiatric disorders have long been assumed to reflect relatively subtle abnormalities of brain development. Although diagnostic brain imaging is well established in pediatric neurology, it has not yet permitted quantitative assessment of brain abnormalities in children with psychiatric illnesses. Recent advances in brain magnetic resonance imaging (MRI) allow re...

The purpose of this hot topic issue of Current Neuropharmacology is to provide a platform to discuss current knowledge regarding oxidative stress as a contributing/causal factor to the pathophysiology of psychiatric illnesses, including schizophrenia, depression, and anxiety. A better understanding of this mechanism may open new venues for prevention and treatment strategies. Due to the lack of...

Depression is frequently a comorbid symptom in patients suffering from neurological or psychiatric illnesses, and this presents a challenge for the differential diagnosis of neuropsychological functioning, especially in the assessment of concentration. The 2 & 7 test was administered to 27 patients with major depression without other neurological or psychiatric illnesses. The average percentile...

The Reasons For Living Inventory has been shown to have good psychometric properties in Western populations for the past three decades. The present study examined the psychometric properties and factor structure of English and Malay version of the Reasons For Living (RFL) Inventory in a sample of clinical outpatients in Malaysia. The RFL is designed to assess an individual's various reasons for...

Inflammatory bowel disease is a group of chronic medical conditions comprising Crohn's disease and ulcerative colitis that involves increased frequency of mental disorders. The most common psychiatric disorders in inflammatory bowel disease are depression and anxiety, however, some epidemiologic and biological evidence suggest that other disorders like bipolar disorder occur more often. Biologi...

OBJECTIVE To examine prospective associations between chronic stress in the parent-child and family systems and subsequent rates of illnesses and the activity of natural killer (NK) cells in children. DESIGN Prospective cohort study. SETTING The Golisano Children's Hospital at Strong, Rochester, NY, from July 1, 2001, to June 30, 2003. PARTICIPANTS One hundred sixty-nine socioeconomically...

BACKGROUND Scant research has adequately addressed the impact of chronic fatigue syndrome on patients' daily activities and quality of life. Enumerating specific problems related to quality of life in chronic fatigue syndrome patients can help us to better understand and manage this illness. This study addresses issues of functional status in persons with chronic fatigue syndrome and other fati...

The salience network (SN) plays a central role in cognitive control by integrating sensory input to guide attention, attend to motivationally salient stimuli and recruit appropriate functional brain-behavior networks to modulate behavior. Mounting evidence suggests that disturbances in SN function underlie abnormalities in cognitive control and may be a common etiology underlying many psychiatr...

Psychiatric disorders and drug and alcohol use disorders commonly co-occur. A growing literature has documented the epidemiology and effects on the course of illness of comorbid psychiatric and substance use disorders (SUDs). Advances in treatment of co-occurring illnesses have progressed more slowly. The current article reviews recent developments in the diagnosis and treatment of co-occurring...