Background: Immune reactions have been reported to be involved in the destruction of retinal ganglion cells (RGCs) in glaucoma. Objective: To investigate the role of major histocompatibility complex class I-related chain A and B (MICA and MICB) molecules in the pathogenesis of glaucoma. Methods: Aqueous humor and serum samples from 15 glaucoma patients and 45 patients with cataract, undergoing ...

AbstractGlaucoma management in pregnant patients is a real challenge, especially when the glaucoma is not controlled with medications. We report the results of 6 incisional glaucoma surgeries for the management of medically uncontrolled glaucoma patients during pregnancy. This retrospective, case series was conducted on the 6 eyes of 3pregnant patients with uncontrolled glaucoma using maximum t...

purpose : to examine the safety and efficacy of simultaneous ahmed glaucoma valve (agv) implantation with intravitreal and intracameral injection of bevacizumab (ivb and icb) in patients with refractory acute neovascular glaucoma (nvg) with very high intraocular pressure (iop) and active neovascularization of the iris (nvi) and/or the angle (nva) methods : in a prospective interventional study,...

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Introduction: The term glaucoma refers to a group of diseases that have a characteristic optic neuropathy with associated visual field loss in common. Intraocular pressure has been considered to be the only causal factor for glaucoma and the only factor that can be manipulated to alter the course of the disease. But considering high intraocular pressure as the only factor responsible for glauco...

The histochemical staining properties of the abnormal material deposited in the anterior segment of the eye in the pseudoexfoliation syndrome and the zonular ligaments of the lens are essentially the same. Both present the staining characteristics of oxytalan, the microfibrillar component of elastic tissue. Reasons are advanced for regarding the pseudoexfoliative material as a product of the ci...

Glaucoma is the leading cause of preventable blindness worldwide. Despite tremendous advances in medical and surgical management of glaucoma in the recent years, the prevalence of glaucoma related blindness is anticipated to increase in the future decades because of the aging population. Stem cells have the potential to change the glaucoma management in several ways. There are several areas of ...

PURPOSE The purpose of the present study was to determine the role of the tumor necrosis factor alpha (TNF-alpha) gene polymorphism G-308A and total serum immunoglobulin E (TsIgE) levels in the onset of pseudoexfoliation glaucoma (PEXG) in Pakistani patients. METHODS The TNF-alpha polymorphism G-308A was analyzed in 122 patients with PEXG and 126 healthy unrelated controls by using polymerase...