Carbapenem-hydrolyzing class D β-lactamases (CHDLs) are enzymes of the utmost clinical importance due to their ability to produce resistance to carbapenems, the antibiotics of last resort for the treatment of various life-threatening infections. The vast majority of these enzymes have been identified in Acinetobacter spp., notably in Acinetobacter baumannii. The OXA-2 and OXA-10 enzymes predomi...

We explore the need for and the architecture of a Problem Solving Environment (PSE) for scholarly communication research through an examination of the problem area it addresses, the problem solving processes that scholarly communication researchers commonly employ, and the existing data sources for this type of research. As scholarly activities in many fields become increasingly heterogeneous a...

BACKGROUND Minimal hepatic encephalopathy (MHE) is clinically undetectable and the diagnosis requires psychometric tests. However, a lack of clarity exists as to whether the tests are in fact able to detect changes in cognition. AIM To examine if the continuous reaction time test (CRT) can detect changes in cognition with anti-HE intervention in patients with cirrhosis and without clinically ...

Periploca sepium (PS) has traditionally been used in oriental medicine for treatment of rheumatoid arthritis (RA). We investigated the aqueous extract of PS (PSE) in its effects on human rheumatoid arthritis-derived fibroblast-like cells. In cell culture studies, PSE inhibited the growth and IL-6 production of the cells in dose dependent manners. The extract of Glycyrrhiza glabra (GG), which ha...

To expedite the pace in conducting genome/proteome analysis, we have developed a Python package called Pse-Analysis. The powerful package can automatically complete the following five procedures: (1) sample feature extraction, (2) optimal parameter selection, (3) model training, (4) cross validation, and (5) evaluating prediction quality. All the work a user needs to do is to input a benchmark ...

The poultry industry has made significant advances in growth rate, feed efficiency, and breast muscle yield through intensive breeding of turkeys. However, a meat quality problem known as pale, soft, exudative (PSE) meat presents the industry with a major challenge during periods of stress, such as the onset of a prolonged heat wave. The biochemical characteristics of PSE turkey are strikingly ...

Sixtynine cases of portal systemic encephalopathy (PSE) (45 cirrhosis, 24 hepatitis) were seen during 15 months. Coma due to acute viral hepatitis occurred in a younger age group as compared to cirrhosis. Upper gastrointestinal bleeding and hepatic necrosis were the main precipitating factors. Most of the patients were in grade Ill (37.6%) and IV (34.7%) coma when first seen. Blood ammonia nitr...

Covid-19 has led to renewed public support for services. Frontline workers symbolize a ideal of service ethos (PSE), though little attention been paid how the managers delivering vital services interpret and mobilize PSE. We show PSE is implemented by reflecting their local contexts. examine theoretical roots challenges newer theories management before illustrating its contemporary manifestatio...

Development of user-friendly Problem Solving Environments (PSEs) is still a challenging task for PSE developers, especially in dealing with the issue of human-PSE communications. This paper proposes a novel way in designing the GridPSi, a Grid-enabled PSE for partial differential equation based physical simulations. The well-designed graphical user interface of this PSE and PDE wizards will gui...

In this study, 4-[5-(4-hydroxyphenyl)-3-aryl-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide derivatives (8-14) were synthesized for the first time by microwave irradiation and their chemical structures were confirmed by 1H NMR, 13C NMR and HRMS. Cytotoxic activities and inhibitory effects on carbonic anhydrase I and II isoenzymes of the compounds were investigated. The compounds 9 (PSE = 4.2), ...