BACKGROUND Hydroxyurea (HU) is the only disease-modifying medication for patients with sickle cell disease (SCD). HU can reduce SCD-related complications but only 35% to 50% of pediatric patients adhere to HU at the rates achieved in clinical trials and this limits its clinical effectiveness. Mobile Directly Observed Therapy (Mobile DOT) is a pilot-tested, electronic, multidimensional, HU adher...

BACKGROUND Preventive treatment goals for blood pressure and cholesterol levels continue to be unmet for many coronary patients. The effect of drug treatment depends on both its appropriateness and the patients' adherence to the treatment regimen. There is a need for adherence interventions that have a measurable effect on clinical outcomes. OBJECTIVE This study aims to evaluate the effects o...

BACKGROUND Regular and timely monitoring of blood glucose (BG) levels in hospitalized patients with diabetes mellitus is crucial to optimizing inpatient glycaemic control. However, methods to quantify timeliness as a measurement of quality of care are lacking. We propose an analytical approach that utilizes BG measurements from electronic records to assess adherence to an inpatient BG monitorin...

objective: bipolar disorder is a severe mental disorder, and its prevalence is around 1% to 2%. despite a vast literature around bipolar disorder, the reasons of its nonadherence and rehospitalization is still obscure. several symptoms of bipolar disorder include changes in activity level, cognitive abilities, speech, and vegetative functions, such as sleep, sexual activity, as well as aggressi...

Objective To undertake meta-analysis and compare treatment effects estimated by the intention-to-treat (ITT) method per-protocol (PP) in randomized controlled trials (RCTs). PP excludes trial participants who are non-adherent to protocol terms of eligibility, interventions, or outcome assessment. Study design setting Five high impact journals were searched for all RCTs published between July 20...

introduction: recognizing the determinants of behavior plays a major role in identification and application of effective strategies for encouraging individuals to follow the intended pattern of behavior. the present study aimed to analyze the university students’ behaviors regarding the amenability to dress code, using the theory of reasoned action (tra). methods: in this cross sectional study,...

background: recently different studies suggested that discontinuation of gonadotrophin releasing hormone analogue (gnrha) at beginning of ovarian stimulation (improvement of ovarian response to gonadotrophins) may have some benefit to poor responder patients in invitro fertilization (ivf) cycles. objective:the efficacy of gnrha stop protocol in poor responder patients in ivf cycles was assessed...

objective: this study was conducted to compare the results of fixed versus flexible gnrh antagonist protocols in controlled ovarian stimulation for intra cytoplasmic sperm injection (icsi) in patients with pcos. materials and methods: a randomized clinical trial was performed on 100 pcos women, who were admitted to a tertiary infertility clinic and were candidate for ivf/icsi. they were divided...

BACKGROUND The 19 Norwegian Emergency medical communication centres (EMCCs) use Norwegian Index for medical emergency assistance (Index) as dispatch guidelines. Little is known about the use of Index, nor its validity. We aimed to document the epidemiology of contacts made to the public emergency medical phone number and the operators' self-reported use of Index as a first step towards a valida...