candida species are the most common cause of opportunistic fungal infection worldwide. due to increasing resistance of fungi against conventional drugs, as well as their side effects, alternative natural products have become a renewed interest. in the current study, the anti-candida activities of scrophularia striata extract were examined. in this experimental study, microdilution assay and wel...

www.landesbioscience.com Cell Cycle 3457 Disease modeling using induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs) promises to reveal underlying pathophysiology, especially for genetic diseases that manifest pathologic tissue development, or in cases where disease tissues are largely destroyed by disease at the time of diagnosis. Shwachman–Diamond syndrome (SDS), a ra...

The aim of the study was to reveal and compare microbiota different carbonate speleothems from two epigenic karst regions (Baradla Csodabogyós caves) in Hungary. Stalagmites, stalactites, soda straws, moonmilks, cave wall surfaces dripping waters were sampled plated on subsurface-environment imitating culture media containing low amount nutrients, minerals extract sediments. Diverse oligo-heter...

screening and identification of moderately halophilic protease producing bacteria from different regions of maharloo, a hypersaline lake in the southern area of iran, were the objectives of this study. in the preliminary screening, 16 isolates exhibited proteolytic activity on saline skim milk agar. all isolates were able to grow comfortably in the media containing 7-15% of salt. protease activ...

proteases catalyze the hydrolysis of peptide bonds in proteins. they are widely distributed in nature, nearly in all plants, animals and microorganisms. plant latex is a rich source of proteases. latex production is unique property of euphorbian plant, which could be a potential source of proteolytic enzymes. the highest proteolytic activity was observed in the latex of pedilanthus tithymaloide...

Gibberellin (GA) hormone signaling occurs through proteolytic and non-proteolytic mechanisms. GA binding to the GA receptor GID1 (GA-INSENSITIVE DWARF1) enables GID1 to bind negative regulators of GA responses called DELLA proteins. In proteolytic GA signaling, the SLEEPY1 (SLY1) F-box protein targets DELLA proteins in the GID1-GA-DELLA complex for destruction through the ubiquitin-proteasome p...

Particulate matter2.5 (PM2.5) is notorious for its strong toxic effects on the cardiovascular, skin, nervous, and reproduction systems. However, the molecular mechanism by which PM2.5 aggravates disease progression is poorly understood, especially in a water-soluble state. In the current study, we investigated the putative physiological effects of aqueous PM2.5 solution on lipoprotein metabolis...