Abstract Ribosome-profiling has uncovered pervasive translation in non-canonical open reading frames, however the biological significance of this phenomenon remains unclear. Using genetic variation from 71,702 human genomes, we assess patterns selection translated upstream frames (uORFs) 5’UTRs. We show that uORF variants introducing new stop codons, or strengthening existing are under strong n...

Abstract Activity‐based protein profiling (ABPP) as a proteomic tool allows measuring the activity of enzyme classes or distinct proteins in their cellular context, annotating function uncharacterized proteins, and investigating target profile small molecule inhibitors. While hydrolases other classes, which exhibit characteristic nucleophilic residue, can be addressed by electrophilic activity‐...

the current youth market is characterized as tech-savvy, variety seekers who has been active in using digital technology in unprecedented ways. the market segment defined here comprises of youth adults between the ages 20 to 30, who are more comfortable with purchasing the smartphones than previous generation. there is fierce competition in smartphone market, due to the large selection of devic...