introduction: binding a monoclonal antibody to tumor associated antigens is an effective method for cancer therapy because these agents can specifically target malignant cells, in fact monoclonal antibodies are effective agents for diagnosis, grading and treatment of different kinds of cancers. methods: in this research, a new monoclonal antibody against colon cancer cells was prepared and anti...

A novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enters into the host cells through an interaction between its surface spike protein (S-protein) and angiotensin-converting enzyme receptors, leading to disease 2019 (COVID-19). Using effective S-protein inhibitors may reduce virulence of virus. Molecular docking was performed evaluate binding affinity 97...

in the near future, design of a new generation of drugs targeting proteins will be required. considering the complex bond between the drug and protein, the structure and stability of the target protein should be considered. so far, a series of in vitro investigations have been conducted with the aim of predicting drug-biological medium interactions. in these studies, use of spectroscopic method...

backgroud: protein-protein interaction, plays a key role in signal transduction in signaling pathways. different approaches are used for prediction of these interactions including experimental and computational approaches. in conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins interact which ca...

Summary Proteins are known to undergo structural changes upon binding partner proteins. However, the prevalence, extent, location, and function of change in protein dynamics due transient protein-protein interactions is not well documented. Here, we have analyzed a dataset 58 complexes three-dimensional structure structures their corresponding unbound forms evaluate induced by binding....

Label-free techniques for quantification of protein-protein interaction often requires protein samples separated from complex media using affinity purification tools such as magnetic nanoparticles. However, the proteins are attached to nanoparticles and need additional preparation steps, including elution immobilization a sensor surface before measurement. To streamline this tedious process, we...

Bisphenol A (BPA) is one of the most widely used chemicals in the plastic industry, which enter the human body through occupational and food contact. In this study, the protein changes in rat cerebral cortex was evaluate in order to evaluate the neurotoxicity of BPA. 24 adult male rats were randomly selected and divided into four groups (n=6) and each group respectively received 0, 0.5, 5 and 5...