Terazosin is one of classic quinazoline-based selective α1-adrenoreceptor antagonists, which is usually used for the treatment of benign prostate hyperplasia (BPH) patients. Several evidences suggest that terazosin can induce apoptosis of prostatic cancer cells in vitro and suppress prostatic tumor growth in vivo, but molecular mechanism contributing to these processes has not yet been fully el...

The clinical significance of prostate cancer extent in prostatic tissue is dependent on the prostatic tissue sample type. For prostate needle core tissue and prostatic chips from transurethral resection of the prostate (TURP), the amount of cancer is of established clinical significance, whereas the intraglandular extent of cancer in radical prostatectomy tissues, although prognostic, is not ro...

We have used microcell fusion-mediated chromosomal transfer to in troduce normal human chromosomes into highly metastatic rodent pros tatic cancer cells to map the location of a metastasis suppressor gene(s). Using this approach, several chromosomal regions have been identified that harbor such metastatic suppressor genes, including human chromo some 11 between p11.2—13 (T. Ichikawa etaL, Can...

Prostate cancer is an affectation acquired in old age, men who develop it may have genetic factors, other predisposing diseases such as benign prostatic hyperplasia and bad habits alcoholism smoking that be the cause of developing affectation. The identification risk factors well their early treatment can significantly reduce morbidity mortality